Tidal volume is a major determinant of cyclic recruitment-derecruitment in acute respiratory distress syndrome

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dc.contributor.authorBruhn, A.
dc.contributor.authorBugedo, D.
dc.contributor.authorRiquelme, F.
dc.contributor.authorVaras, J.
dc.contributor.authorRetamal, J.
dc.contributor.authorBesa, C.
dc.contributor.authorCabrera, C.
dc.contributor.authorBugedo, G.
dc.date.accessioned2024-01-10T12:10:09Z
dc.date.available2024-01-10T12:10:09Z
dc.date.issued2011
dc.description.abstractBackground. Overdistension and cyclic recruitment-derecruitment contribute to ventilator-induced lung injury. High tidal volumes are thought to increase mortality mainly by inducing overdistension. However, experimental evidence suggests that tidal volume (VT) may also influence cyclic recruitment-derecruitment. Our main goal was to determine whether high tidal volumes increase cyclic recruitment-derecruitment in acute respiratory distress syndrome (ARDS) patients, as measured by dynamic computed tomography (CT).
dc.description.abstractMethods. We studied 9 ARDS patients with diffuse attenuations on CT who underwent a protocol including 2 ventilatory modes: (a) VT 6 mL/kg, respiratory rate 30/min, PEEP 9 cmH(2)O, (b) VT 12 mL/kg, respiratory rate 15/min, PEEP 9 cmH(2)O. A dynamic computed tomography of 8 seconds on a fixed transverse region was performed during each ventilator mode. Cyclic recruitment-derecruitment was determined as non-aerated tissue variation between inspiration and expiration and was expressed as % of lung tissue weight.
dc.description.abstractResults. VT 12 mL/kg exhibited less non-aerated tissue at expiration compared to VT 6 ml/kg (40.15 [35.94-56.00] and 45.31 [37.95-59.32], respectively, P<0.05). However, VT 12 ml/kg increased cyclic recruitment-derecruitment compared to VT 6 mL/kg (7.32 [6.58-9.29] mL/kg vs. 4.51 [3.42-5.75] mL/kg, P<0.01). Tidal hyperinflation was also larger at VT 12 mL/kg (0.55 [0.27-2.24] vs. 0.24 [0.18-0.83], P<0.01).
dc.description.abstractConclusion. High tidal volume is a major determinant of cyclic recruitment-derecruitment in ARDS patients with diffuse attenuations. (Minerva Anestesiol 2011;77:418-26)
dc.description.funderFondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT)
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.eissn1827-1596
dc.identifier.issn0375-9393
dc.identifier.pubmedidMEDLINE:21483386
dc.identifier.wosidWOS:000290120900006
dc.information.autorucMedicina;Besa C ;S/I;167343
dc.information.autorucMedicina;Bruhn A;S/I;741
dc.information.autorucMedicina;Bugedo D;S/I;142562
dc.information.autorucMedicina;Bugedo G ;S/I;60490
dc.information.autorucMedicina;Cabrera C ;S/I;117381
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final426
dc.pagina.inicio418
dc.publisherEDIZIONI MINERVA MEDICA
dc.revistaMINERVA ANESTESIOLOGICA
dc.rightsacceso restringido
dc.subjectVentilator-induced lung injury
dc.subjectRespiratory distress syndrome, adult
dc.subjectTomography, X-ray computed
dc.subjectVentilation, mechanical
dc.subjectACUTE LUNG INJURY
dc.subjectEND-EXPIRATORY PRESSURE
dc.subjectTRANSPULMONARY PRESSURE
dc.subjectMECHANICAL VENTILATION
dc.subjectREGIONAL-DISTRIBUTION
dc.subjectDYNAMIC CT
dc.subjectCOLLAPSE
dc.subjectTIME
dc.subjectDISTRIBUTIONS
dc.subjectMETAANALYSIS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTidal volume is a major determinant of cyclic recruitment-derecruitment in acute respiratory distress syndrome
dc.typeartículo
dc.volumen77
sipa.codpersvinculados167343
sipa.codpersvinculados741
sipa.codpersvinculados142562
sipa.codpersvinculados60490
sipa.codpersvinculados117381
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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