Autograft versus allograft with or without demineralized bone matrix in posterolateral lumbar fusion in rabbits - Laboratory investigation

Simple item page
dc.contributor.authorUrrutia, Julio
dc.contributor.authorThumm, Nicolas
dc.contributor.authorApablaza, Daniel
dc.contributor.authorPizarro, Felipe
dc.contributor.authorZylberberg, Alejandro
dc.contributor.authorQuezada, Felipe
dc.date.accessioned2024-01-10T13:46:15Z
dc.date.available2024-01-10T13:46:15Z
dc.date.issued2008
dc.description.abstractObject. Posterolateral spinal fusions are performed to treat different spinal disorders. Autograft continues to be the gold standard; it is, however, associated with donor site morbidity and limited sources. Allograft has been used, but has been reported to result in lower fusion rates. Demineralized bone matrix (DBM) has also been used and reportedly increases the fusion rate in a variety of critical defect models. Different forms of DBM are available, not all have been independently studied. To evaluate the effect of a xenogenic DBM added to allograft on the fusion rate of posterolateral lumbar spine arthrodesis the authors designed an experimental study comparing posterolateral fusion rate using autograft, allograft, and allograft plus a xenogenic DBM in a validated animal model.
dc.description.abstractMethods. A bilateral, 1-level (L4-5) intertransverse process fusion was performed in 45 male New Zealand rabbits. Iliac crest bone graft was harvested bilaterally from each rabbit. The rabbits were randomly assigned to 3 groups: Group 1, Autograft, 15 rabbits; Group II, Allograft, 15 rabbits; and Group III, Allograft plus DBM in a paste form (Dynagraft). The animals were killed 8 weeks after surgery. Fusion was assessed radiographically and by manual palpation by 2 independent observers. The results were analyzed using the Fisher exact test and chi-square test.
dc.description.abstractResults. The fusion rate was 46.6% (7 of 15 rabbits) in the autograft group, 33.3% (5 of 15 rabbits) in the allograft group, and 33.3% (5 of 15 rabbits) in the allograft plus DBM group (p > 0.05).
dc.description.abstractConclusions. Autograft produced a higher fusion rate than allograft in this spinal fusion rabbit model, but the difference was not statistically significant. Allograft plus xenogenic DBM showed the same fusion rate as allograft alone.
dc.fechaingreso.objetodigital2024-05-23
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3171/SPI/2008/9/7/084
dc.identifier.eissn1547-5646
dc.identifier.issn1547-5654
dc.identifier.pubmedidMEDLINE:18590417
dc.identifier.urihttps://doi.org/10.3171/SPI/2008/9/7/084
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79139
dc.identifier.wosidWOS:000257201700014
dc.information.autorucMedicina;Apablaza D;S/I;129229
dc.information.autorucMedicina;Pizarro F;S/I;135686
dc.information.autorucMedicina;Quezada F;S/I;1004776
dc.information.autorucMedicina;Thumm N;S/I;13929
dc.information.autorucMedicina;Urrutia J;S/I;69910
dc.information.autorucMedicina;Zylberberg A;S/I;4220
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final89
dc.pagina.inicio84
dc.publisherAMER ASSOC NEUROLOGICAL SURGEONS
dc.revistaJOURNAL OF NEUROSURGERY-SPINE
dc.rightsacceso restringido
dc.subjectallograft
dc.subjectautograft
dc.subjectbone graft
dc.subjectdemineralized bone matrix
dc.subjectrabbit model
dc.subjectspine fusion
dc.subjectDONOR SITE PAIN
dc.subjectSPINAL-FUSION
dc.subjectINTERBODY FUSION
dc.subjectMORPHOGENETIC PROTEIN-2
dc.subjectATHYMIC RAT
dc.subjectILIAC CREST
dc.subjectMODEL
dc.subjectSURGERY
dc.subjectARTHRODESIS
dc.subjectRHBMP-2
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAutograft versus allograft with or without demineralized bone matrix in posterolateral lumbar fusion in rabbits - Laboratory investigation
dc.typeartículo
dc.volumen9
sipa.codpersvinculados129229
sipa.codpersvinculados135686
sipa.codpersvinculados1004776
sipa.codpersvinculados13929
sipa.codpersvinculados69910
sipa.codpersvinculados4220
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2024-05-23. Autograft versus allograft with or without demineralized bone matrix in posterolateral lumbar fusion in rabbits - Laboratory investigation.pdf
Size:
3.24 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas