Induction of SARS-CoV-2 neutralizing antibodies by CoronaVac and BNT162b2 vaccines in naive and previously infected individuals

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dc.contributor.authorMuena, Nicolas A.
dc.contributor.authorGarcia-Salum, Tamara
dc.contributor.authorPardo-Roa, Catalina
dc.contributor.authorJose Avendano, Maria
dc.contributor.authorSerrano, Eileen F.
dc.contributor.authorLevican, Jorge
dc.contributor.authorAlmonacid, Leonardo, I
dc.contributor.authorValenzuela, Gonzalo
dc.contributor.authorPoblete, Estefany
dc.contributor.authorStrohmeier, Shirin
dc.contributor.authorSalinas, Erick
dc.contributor.authorMunoz, Andres
dc.contributor.authorHaslwanter, Denise
dc.contributor.authorDieterle, Maria Eugenia
dc.contributor.authorJangra, Rohit K.
dc.contributor.authorChandran, Kartik
dc.contributor.authorGonzalez, Claudia
dc.contributor.authorRiquelme, Arnoldo
dc.contributor.authorKrammer, Florian
dc.contributor.authorTischler, Nicole D.
dc.contributor.authorMedina, Rafael A.
dc.date.accessioned2024-01-31T14:30:06Z
dc.date.available2024-01-31T14:30:06Z
dc.date.issued2022
dc.description.abstractInterpretation The decay of nAbs titres in previously infected individuals over time indicates that vaccination is needed to boost humoral memory responses. Immunization of naydve individuals with two doses of CoronaVac induced nAbs titres that were significantly lower to that of convalescent patients, and similar to vaccination with one dose of BTN162b2. The real life effectiveness for CoronaVac in Chile was higher than estimated; indicating that lower titres and additional cellular immune responses induced by CoronaVac might afford protection in a highly immunized population. Nevertheless, the lower nAb titre induced by two doses of CoronaVac as compared to the BTN162b2 vaccine in naydve individuals, highlights the need of booster immunizations over time to maintain protec-tive levels of antibody, particularly with the emergence of new SARS-CoV-2 variants. Funding FONDECYT 1161971, 1212023, 1181799, FONDECYT Postdoctorado 3190706 and 3190648, ANID Becas/ Doctorado Nacional 21212258, PIA ACT 1408, CONICYT REDES180170, Centro Ciencia & Vida, FB210008, Finan-ciamiento Basal para Centros Cient?ficos y Tecnol?ogicos de Excelencia grants from the Agencia Nacional de Inves-tigaci?on y Desarrollo (ANID) of Chile; NIH-NIAD grants U19AI135972, R01AI132633 and contracts HHSN272201400008C and 75N93019C00051; the JPB Foundation, the Open Philanthropy Project grant 2020-215611 (5384); and by anonymous donors. The funders had no role in study design, data collection and analysis, deci-sion to publish, or preparation of the manuscript. Copyright (c) 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
dc.description.abstract<comment>Superscript/Subscript Available</comment
dc.description.funderSwiss National Centre of Competence in Research LIVES -Overcoming Vulnerability: Life Course Perspectives
dc.description.funderSwiss National Science Foundation (SNSF)
dc.description.funderNORFACE DIAL programme
dc.description.funderAgencia Nacional de Investigacion y Desarrollo (ANID), Chile
dc.format.extent30 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.ebiom.2022.103972
dc.identifier.eissn1469-1779
dc.identifier.issn2352-3964
dc.identifier.scopusidSCOPUS_ID:85086945586
dc.identifier.urihttps://doi.org/10.1016/j.ebiom.2022.103972
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81119
dc.identifier.wosidWOS:000805144700007
dc.information.autorucFacultad de Medicina; Pardo Roa, Catalina; S/I; 225251
dc.issue.numero2
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final95
dc.pagina.inicio71
dc.relation.ispartofWorld Congress of Cardiology, MAY 18-21, 2008, Buenos Aires, ARGENTINA
dc.revistaAGEING & SOCIETY
dc.rightsregistro bibliográfico
dc.subjectCOVID-19
dc.subjectSerological response
dc.subjectNeutralizing antibody persistence
dc.subjectSARS-CoV-2 vaccines
dc.subjectVaccination boost
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleInduction of SARS-CoV-2 neutralizing antibodies by CoronaVac and BNT162b2 vaccines in naive and previously infected individuals
dc.typeartículo
dc.volumen78
sipa.codpersvinculados225251
sipa.indexWOS
sipa.trazabilidadCarga SIPA;31-01-2024
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