Plasma protein Z concentrations in pregnant women with idiopathic intrauterine bleeding and in women with spontaneous preterm labor

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dc.contributor.authorKusanovic, Juan Pedro
dc.contributor.authorEspinoza, Jimmy
dc.contributor.authorRomero, Roberto
dc.contributor.authorHoppensteadt, Debra
dc.contributor.authorNien, Jyh Kae
dc.contributor.authorKim, Chong Jai
dc.contributor.authorErez, Offer
dc.contributor.authorSoto, Eleazar
dc.contributor.authorFareed, Jawed
dc.contributor.authorEdwin, Sam
dc.contributor.authorChaiworapongsa, Tinnakorn
dc.contributor.authorThan, Nador G.
dc.contributor.authorYoon, Bo Hyun
dc.contributor.authorGomez, Ricardo
dc.contributor.authorPapp, Zoltan
dc.contributor.authorHassan, Sonia S.
dc.date.accessioned2024-01-10T13:52:10Z
dc.date.available2024-01-10T13:52:10Z
dc.date.issued2007
dc.description.abstractObjectives. Preterm parturition has been associated with decidual vascular disorders and excessive thrombin generation. The objective of this study was to examine maternal plasma concentrations of protein Z in normal pregnancies, as well as in those presenting with spontaneous preterm labor (PTL) and intrauterine bleeding during pregnancy.
dc.description.abstractStudy design. A cross-sectional study was designed to include patients with preterm labor and intact membranes and those with idiopathic intrauterine bleeding during pregnancy. Protein Z plasma concentrations were measured in the following groups: (1) normal pregnant women (n = 71); (2) patients at term with (n = 67) and without labor (n = 88); (3) patients with spontaneous PTL before 34 weeks who were classified into: (a) PTL with intra-amniotic infection/inflammation (IAI; n = 35), (b) PTL without IAI (n = 54), and (c) patients with PTL who delivered at term (n = 49); and (4) patients with idiopathic intrauterine bleeding in the second and third trimester who were divided into: (a) subsequent spontaneous PTL and delivery, and (b) term delivery. Maternal plasma protein Z concentration was measured by a specific and sensitive immunoassay. Moreover, the amniotic fluid concentration of protein Z was determined in a subset of patients with preterm labor (n = 30).
dc.description.abstractResults. (1) There was no correlation between maternal plasma protein Z concentration and gestational age in normal pregnant women. (2) The mean maternal plasma concentration of protein Z was significantly lower in women during spontaneous labor at term than in those not in labor (mean 2.15 mg/mL (95% CI 2.01-2.29) vs. mean 2.45 +/- 0.52 mg/mL (95% CI 2.34 -2.56), respectively; p = 0.001). (3) Women with PTL without IAI who delivered preterm had a significantly lower mean protein Z concentration than normal pregnant women (mean 2.12 mg/mL (95% CI 1.98-2.26) vs. mean 2.39 mg/mL (95% CI 2.28-2.5); p = 0.008). (4) Of interest, PTL with IAI was not associated with lower plasma concentrations of protein Z, nor were those with PTL who delivered at term (p > 0.05 for each). (5) No differences were found in the maternal plasma concentrations of anti-protein Z antibodies between normal pregnancies and those with spontaneous PTL. (6) Patients with idiopathic intrauterine bleeding who had spontaneous PTL and delivery had a significantly lower mean plasma protein Z concentration than those who delivered at term (mean 1.24 mg/mL (95% CI 1.08-1.4) vs. mean 1.49 +/- 0.47 mg/mL (95% CI 1.33-1.65), respectively; p = 0.03). (7) Amniotic fluid was found to contain immunoreactive protein Z.
dc.description.abstractConclusions. (1) Patients with PTL leading to preterm delivery in the absence of IAI had a significantly lower plasma concentration of protein Z than those with normal pregnancies. (2) Patients with idiopathic intrauterine bleeding and subsequently spontaneous PTL and delivery had a significantly lower plasma concentration of protein Z than those with idiopathic intrauterine bleeding who delivered at term. (3) Protein Z was present in the amniotic fluid of patients with PTL.
dc.description.abstractCollectively, these observations suggest that a subgroup of patients with PTL have a hemostatic disorder that involves bleeding/thrombosis as a mechanism of disease.
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT
dc.description.funderIntramural NIH HHS
dc.fechaingreso.objetodigital2024-05-09
dc.format.extent11 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1080/14767050701398272
dc.identifier.eissn1476-4954
dc.identifier.issn1476-7058
dc.identifier.pubmedidMEDLINE:17674255
dc.identifier.urihttps://doi.org/10.1080/14767050701398272
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79648
dc.identifier.wosidWOS:000247611800004
dc.information.autorucMedicina;Gómez R;S/I;80926
dc.information.autorucMedicina;Nien J;S/I;2778
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final463
dc.pagina.inicio453
dc.publisherTAYLOR & FRANCIS LTD
dc.revistaJOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
dc.rightsacceso restringido
dc.subjectcoagulation
dc.subjectpregnancy
dc.subjectprotein Z
dc.subjectamniotic fluid
dc.subjectparturition
dc.subjectthrombin
dc.subjectanti-protein Z antibodies
dc.subjectvaginal bleeding
dc.subjectFACTOR-V-LEIDEN
dc.subjectZ DEFICIENCY
dc.subjectISCHEMIC STROKE
dc.subjectAMNIOTIC-FLUID
dc.subjectPROTHROMBOTIC PHENOTYPE
dc.subjectINTRAAMNIOTIC INFECTION
dc.subjectPREMATURE LABOR
dc.subjectZ ANTIBODIES
dc.subjectPARTURITION
dc.subjectINHIBITOR
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.titlePlasma protein Z concentrations in pregnant women with idiopathic intrauterine bleeding and in women with spontaneous preterm labor
dc.typeartículo
dc.volumen20
sipa.codpersvinculados80926
sipa.codpersvinculados2778
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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