Neuromyelitis optica spectrum disorders: Profile of a cohort according to the 2015 diagnostic criteria

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dc.catalogadorjwg
dc.contributor.authorUribe San Martin, Reinaldo Moisés
dc.contributor.authorCiampi Diaz, Ethel Leslie
dc.contributor.authorGalilea Izquierdo, Antonia
dc.contributor.authorSandoval Rubio, Patricio Alberto Mario
dc.contributor.authorMiranda Vera, Héctor David
dc.contributor.authorMellado Talesnik, Patricio Andrés
dc.contributor.authorCárcamo Rodríguez, Claudia Andrea
dc.contributor.authorAlbornoz Cruz, Juan Pablo
dc.contributor.authorHuete Garin, Isidro Álvaro
dc.date.accessioned2024-01-16T12:46:57Z
dc.date.available2024-01-16T12:46:57Z
dc.date.issued2017
dc.description.abstractThe new 2015 criteria for neuromyelitis optica spectrum disorders (NMOSD) have been recently incorporated in the study of different international cohorts. Aim. To describe clinical-radiological characteristics and prognostic factors in patients with NMOSD according to the 2015 criteria. Patients and methods. Retrospective analysis of 36 patients diagnosed with NMOSD according to serologic AQP4 status (positive, negative, unknown and negative + unknown). Clinical and radiological characteristics were compared and possible disability prognostic factors were evaluated. Results. AQP4 were positive in 7 patients, negative in 12 and unknown in 17. Age of presentation was 36.6 ± 16 years, with higher female proportion (4:1). Mean disease duration was 7.4 ± 7.6 years. Most frequent presenting symptoms were acute myelitis (61%), optic neuritis (33%) and area postrema syndrome (11%). Most frequent MRI lesion was longitudinally extensive transverse myelitis (75%). All patients received acute treatment during attacks, and preventive treatment was used in 81% (azathioprine and rituximab mostly prescribed). Median EDSS was 2.0 at the end of follow-up. No differences were observed in any of the variables comparing serologic status. Age of first attack was prognostic, with direct correlation with EDSS. First attack in < 30 years was protective, meanwhile > 50 years old patients had increased risk of disability. Conclusions. The 2015 criteria allow the description and classification of NMOSD patients within different cohorts. Age of first attack seems to be a prognostic factor for developing disability.
dc.fuente.origenScopus
dc.identifier.doi10.33588/rn.6505.2017037
dc.identifier.issn02100010
dc.identifier.pubmedid28849860
dc.identifier.scopusidSCOPUS_ID:85032478267
dc.identifier.urihttps://doi.org/10.33588/rn.6505.2017037
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80474
dc.identifier.urihttps://www.neurologia.com/pdf/6505/bs050193.pdf
dc.information.autorucEscuela de Medicina; Uribe San Martin Reinaldo Moises; 0000-0002-3422-7962; 127201
dc.information.autorucEscuela de Medicina; Ciampi Diaz Ethel Leslie; 0000-0002-7330-5433; 132794
dc.information.autorucEscuela de Medicina; Galilea Izquierdo Antonia; ; 237994
dc.information.autorucEscuela de Medicina; Huete Garin Isidro Alvaro; 0000-0002-8746-1111; 731
dc.information.autorucEscuela de Medicina; Albornoz Cruz Juan Pablo; ; 185025
dc.information.autorucEscuela de Medicina; Carcamo Rodriguez Claudia Andrea; 0000-0002-9430-216X; 562
dc.information.autorucEscuela de Medicina; Mellado Talesnik Patricio Andres; ; 3552
dc.information.autorucEscuela de Medicina; Miranda Vera Hector David; ; 3526
dc.information.autorucEscuela de Medicina; Sandoval Rubio Patricio Alberto Mario; 0000-0002-4656-558X; 102093
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final202
dc.pagina.inicio193
dc.publisherRevista de Neurologia
dc.revistaRevista de Neurología
dc.rightsacceso restringido
dc.subjectAnti-aquaporin 4 antibodies
dc.subjectDevic’s disease
dc.subjectDiagnostic criteria
dc.subjectMyelitis
dc.subjectNeuromyelitis optica
dc.subjectOptic neuritis
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleNeuromyelitis optica spectrum disorders: Profile of a cohort according to the 2015 diagnostic criteria
dc.title.alternativeEspectro de neuromielitis óptica: Descripción de una cohorte según los criterios diagnósticos de 2015
dc.typeartículo
dc.volumen65
sipa.codpersvinculados127201
sipa.codpersvinculados132794
sipa.codpersvinculados237994
sipa.codpersvinculados731
sipa.codpersvinculados185025
sipa.codpersvinculados562
sipa.codpersvinculados3552
sipa.codpersvinculados3526
sipa.codpersvinculados102093
sipa.trazabilidadScopus;12-10-2021
sipa.trazabilidadORCID;2024-01-08
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