Persistent sepsis-induced hypotension without hyperlactatemia: A distinct clinical and physiological profile within the spectrum of septic shock

Simple item page
dc.contributor.authorHernández P., Glenn
dc.contributor.authorBruhn, Alejandro
dc.contributor.authorCastro, R.
dc.contributor.authorPedreros, C.
dc.contributor.authorRovegno Echavarria, Maxiliano
dc.contributor.authorKattan Tala, Eduardo José
dc.contributor.authorVeas, E.
dc.contributor.authorFuentealba, A.
dc.contributor.authorRegueira Heskia, Tomás
dc.contributor.authorRuiz, C.
dc.contributor.authorInce, C.
dc.date.accessioned2020-01-12T03:51:27Z
dc.date.available2020-01-12T03:51:27Z
dc.date.issued2012
dc.description.abstractIntroduction. A subgroup of septic shock patients will never develop hyperlactatemia despite being subjected to a massive circulatory stress. Maintenance of normal lactate levels during septic shock is of great clinical and physiological interest. Our aim was to describe the clinical, hemodynamic, perfusion, and microcirculatory profiles associated to the absence of hyperlactatemia during septic shock resuscitation. Methods. We conducted an observational study in septic shock patients undergoing resuscitation. Serial clinical, hemodynamic, and perfusion parameters were registered. A single sublingual microcirculatory assessment was performed in a subgroup. Patients evolving with versus without hyperlactatemia were compared. Results. 124 septic shock patients were included. Patients without hyperlactatemia exhibited lower severity scores and mortality. They also presented higher platelet counts and required less intensive treatment. Microcirculation was assessed in 45 patients. Patients without hyperlactatemia presented higher PPV and MFI values. Lactate was correlated to several microcirculatory parameters. No difference in systemic flow parameters was observed. Conclusion. Persistent sepsis-induced hypotension without hyperlactatemia is associated with less organ dysfunctions and a very low mortality risk. Patients without hyperlactatemia exhibit less coagulation and microcirculatory derangements despite comparable macrohemodynamics. Our study supports the notion that persistent sepsis-induced hypotension without hyperlactatemia exhibits a distinctive clinical and physiological profile.
dc.fuente.origenFacultad de Medicina
dc.identifier.doi10.1155/2012/536852
dc.identifier.issn2090-1305
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/27411
dc.language.isoen
dc.revistaCritical Care Research and Practicees_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherShock sépticoes_ES
dc.subject.otherSepsis - Terapiaes_ES
dc.subject.otherFisiopatologíaes_ES
dc.titlePersistent sepsis-induced hypotension without hyperlactatemia: A distinct clinical and physiological profile within the spectrum of septic shockes_ES
dc.typeartículo
dc.volumenVol. 2012
sipa.codpersvinculados98874
sipa.codpersvinculados741
sipa.codpersvinculados4537
sipa.codpersvinculados18434
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Persistent sepsis-induced hypotension without hyperlactatemia- A distinct clinical and physiological profile within the spectrum of septic shock.pdf
Size:
493.15 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas