Risk Factors for High-Risk Human Papillomavirus Infection and Cofactors for High-Grade Cervical Disease in Peru

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dc.contributor.authorAlmonte, Maribel
dc.contributor.authorFerreccio, Catterina
dc.contributor.authorGonzales, Miguel
dc.contributor.authorDelgado, Jose Manuel
dc.contributor.authorBuckley, C. Hilary
dc.contributor.authorLuciani, Silvana
dc.contributor.authorRobles, Sylvia C.
dc.contributor.authorWinkler, Jennifer L.
dc.contributor.authorTsu, Vivien D.
dc.contributor.authorJeronimo, Jose
dc.contributor.authorCuzick, Jack
dc.contributor.authorSasieni, Peter
dc.date.accessioned2024-01-10T12:42:11Z
dc.date.available2024-01-10T12:42:11Z
dc.date.issued2011
dc.description.abstractObjective: To evaluate the association between potential risk factors for high-risk human papillomavirus (HR-HPV) infection and cofactors for cervical intraepithelial lesions grade 2 or worse (CIN2+) in women attending cervical screening in Amazonian Peru.
dc.description.abstractMaterials and Methods: Participants completed a risk factor questionnaire before screening. High-risk human papillomavirus infection was determined by Hybrid Capture II. Logistic regression was used to evaluate associations between potential risk factors for HR-HPV infection and between cofactors and risk of CIN2+ among women with HR-HPV infection.
dc.description.abstractResults: Screening and questionnaires were completed by 5435 women aged 25 to 49 years. The prevalence of HR-HPV was 12.6% (95% confidence interval [CI], 11.8%-13.6%) and decreased by age. Early age at first sexual intercourse and several lifetime sexual partners increased the risk of having HR-HPV (age-adjusted odds ratio [AOR] of age at first sexual intercourse <18 vs >= 20, 1.5; 95% CI, 1.2-2.0; AOR of >= 5 lifetime sexual partners vs 1, 2.1; 95% CI, 1.4-3.2). Among women with HR-HPV infection, those with no schooling (AOR relative to 1-5 years of schooling, 3.2; 95% CI, 1.3-8.3) and those with parity >= 3 (AOR relative to parity <3, 2.6; 95% CI, 1.4-4.9) were at increased risk of CIN2+. The effect of parity was stronger for cancer (AOR of parity >= 3 vs <3, 8.3; 95% CI, 1.0-65.6). Further analysis showed that the association between parity and CIN2+ was restricted to women younger than 40. Most women (83%) had previously been screened. Sixty-four percent of CIN2+ cases detected in this study occurred in women who reported having had a Papanicolaou test in the previous 3 years. Only 4 of 20 cancers were detected in women never screened before. Having had a previous abnormal Papanicolaou test increased the risk of CIN2+ (OR, 16.1; 95% CI, 6.2-41.9).
dc.description.abstractConclusion: Among women with HR-HPV, high parity (in young women), no schooling, lack of good-quality screening and of adequate follow-up care are the main risk factors for high-grade cervical disease in Peru.
dc.description.funderCancer Research UK
dc.fechaingreso.objetodigital2024-05-22
dc.format.extent10 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1097/IGC.0b013e3182288104
dc.identifier.eissn1525-1438
dc.identifier.issn1048-891X
dc.identifier.pubmedidMEDLINE:21892094
dc.identifier.urihttps://doi.org/10.1097/IGC.0b013e3182288104
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77489
dc.identifier.wosidWOS:000298081800023
dc.information.autorucMedicina;Ferreccio F;S/I;99684
dc.issue.numero9
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1663
dc.pagina.inicio1654
dc.publisherBMJ PUBLISHING GROUP
dc.revistaINTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
dc.rightsacceso restringido
dc.subjectHuman papillomavirus
dc.subjectCervical cancer
dc.subjectCervical screening
dc.subjectRisk factors
dc.subjectPOOLED ANALYSIS
dc.subjectHPV INFECTION
dc.subjectWOMEN
dc.subjectCANCER
dc.subjectPREVALENCE
dc.subjectNEOPLASIA
dc.subjectEPIDEMIOLOGY
dc.subjectCYTOLOGY
dc.subjectAGE
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.titleRisk Factors for High-Risk Human Papillomavirus Infection and Cofactors for High-Grade Cervical Disease in Peru
dc.typeartículo
dc.volumen21
sipa.codpersvinculados99684
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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