Compassionate use of ruxolitinib in acute and chronic graft versus host disease refractory both to corticosteroids and extracorporeal photopheresis

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dc.contributor.authorSarmiento Maldonado, Mauricio
dc.contributor.authorBertín Cortes Monroy, Pablo
dc.contributor.authorJara Arias, Verónica.
dc.contributor.authorSoto Donoso, Katherine.
dc.contributor.authorUribe González, Pablo Francisco
dc.contributor.authorOcqueteau Tachini, Mauricio
dc.contributor.authorRamírez Villanueva, Pablo Antonio
dc.contributor.authorPerez Simón, José Antonio.
dc.date.accessioned2019-10-17T14:15:15Z
dc.date.available2019-10-17T14:15:15Z
dc.date.issued2017
dc.date.updated2019-10-14T19:08:56Z
dc.description.abstractAbstract Background Ruxolitinib is a potent inhibitor of JAK1/2 with proven efficacy in myelofibrosis. In recent years, research in graft versus host disease (GVHD) has revealed the role of activation of JAK pathways in alloreactive lymphocytes. Some reports have shown significant responses in refractory GVHD patients. Cases presentation In this report we present our experience in 8 patients with acute or chronic GVHD with refractoriness to steroids and extracorporeal photopheresis treated with ruxolitinib. Three patients had acute GVHD (1 pulmonary, 2 cutaneous, 1 multi-systemic) and 5 had chronic GVHD (3 cutaneous); 85% obtained an overall response and 50% a complete response with a tolerable toxicity profile. Conclusions In our series, Ruxolitinib was very active as a rescue therapy for patients with acute or chronic GVHD refractory to standard treatment.
dc.fuente.origenBiomed Central
dc.identifier.citationExperimental Hematology & Oncology. 2017 Dec 02;6(1):32
dc.identifier.doi10.1186/s40164-017-0092-3
dc.identifier.urihttps://doi.org/10.1186/s40164-017-0092-3
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/26681
dc.issue.numeroNo. 32
dc.language.isoen
dc.pagina.final9
dc.pagina.inicio1
dc.revistaExperimental Hematology & Oncologyes_ES
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherMédula ósea - Tratamientoes_ES
dc.subject.otherEnfermedad de injerto contra huéspedes_ES
dc.subject.otherCorticosteroides - Uso terapéuticoes_ES
dc.titleCompassionate use of ruxolitinib in acute and chronic graft versus host disease refractory both to corticosteroids and extracorporeal photopheresises_ES
dc.typeartículo
dc.volumenVol. 6
sipa.codpersvinculados167160
sipa.codpersvinculados99372
sipa.codpersvinculados9032
sipa.codpersvinculados71377
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