Association between red blood cell transfusion and adverse clinical outcomes is Independent of cardiac history: a multicenter observational InPUT study analysis

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dc.article.number526
dc.catalogadorgjm
dc.contributor.authorKimmoun, Antoine
dc.contributor.authorGirerd, Nicolas
dc.contributor.authorDuarte, Kevin
dc.contributor.authorBruno, Jolie
dc.contributor.authorSchenk, Jimmy
dc.contributor.authorLevy, Bruno
dc.contributor.authorBaudry, Guillaume
dc.contributor.authorRaasveld, Senta J.
dc.contributor.authorde Bruin, Sanne
dc.contributor.authorReuland, Merijn C.
dc.contributor.authorvan den Oord, Claudia
dc.contributor.authorSchaap, Caroline M.
dc.contributor.authorBakker, Jan
dc.contributor.authorCecconi, Maurizio
dc.contributor.authorFeldheiser, Aarne
dc.contributor.authorMeier, Jens
dc.contributor.authorMcQuilten, Zoe
dc.contributor.authorMüller, Marcella C. A.
dc.contributor.authorScheeren, Thomas W. L.
dc.contributor.authorAubron, Cécile
dc.contributor.authorFlint, Andrew W. J.
dc.contributor.authorHamid, Tarikul
dc.contributor.authorPiagnerelli, Michaël
dc.contributor.authorMahečić, Tina T.
dc.contributor.authorBenes, Jan
dc.contributor.authorRussell, Lene
dc.contributor.authorAguirre-Bermeo, Hernan
dc.contributor.authorTriantafyllopoulou, Konstantina
dc.contributor.authorChantziara, Vasiliki
dc.contributor.authorGurjar, Mohan
dc.contributor.authorMyatra, Sheila N.
dc.contributor.authorPota, Vincenzo
dc.contributor.authorElhadi, Muhammed
dc.contributor.authorGawda, Ryszard
dc.contributor.authorMourisco, Mafalda
dc.contributor.authorLance, Marcus
dc.contributor.authorNeskovic, Vojislava
dc.contributor.authorPodbregar, Matej
dc.contributor.authorLlau, Juan V.
dc.contributor.authorQuintana-Diaz, Manual
dc.contributor.authorCronhjort, Maria
dc.contributor.authorPfortmueller, Carmen A.
dc.contributor.authorYapici, Nihan
dc.contributor.authorNielsen, Nathan
dc.contributor.authorShah, Akshay
dc.contributor.authorde Grooth, Harm-Jan
dc.contributor.authorVlaar, Alexander P. J.
dc.contributor.authorMebazaa, Alexandre
dc.date.accessioned2026-01-23T15:39:12Z
dc.date.available2026-01-23T15:39:12Z
dc.date.issued2025
dc.date.updated2026-01-05T14:43:38Z
dc.description.abstractPurpose Red-blood-cell (RBC) transfusion is one of the most frequent interventions in critical care patients. While patients with acute cardiac conditions are more likely to receive transfusions at higher haemoglobin thresholds than other critically ill patients, data on RBC transfusion practice for critically ill patients with pre-existing cardiac conditions are scarce. Methods Using the International Point-Prevalence Study of Intensive-Care Unit Transfusion Practices cohort, weighted logistic regression investigated the association between the RBC units transfused and the primary composite outcome of 28-day mortality, new-onset acute kidney injury or ventilatory weaning failure. Interactions with cardiac history (acute coronary syndrome and/or heart failure) were tested. Results Cardiac history was present in 746 of 3643 patients (20%) and 894 of 3643 (25%) received at least one RBC unit. Transfusion rates were similar in patients with and without cardiac history (25% vs. 24%; p = 0.51). Among transfused patients, median nadir haemoglobin during ICU stay was slightly higher in those with cardiac history (7.6 g/dL vs. 7.4 g/dL respectively; p = 0.007), whereas stated haemoglobin transfusion threshold did not statistically differ (8.5 g/dL vs. 8.0 g/dL; p = 0.11). Each additional RBC unit increased the odds of the composite outcome in the whole cohort (2.18, 95% CI 1.85–2.56, p < 0.0001), without interaction with cardiac history (p = 0.44). Conclusions RBC transfusion was commonly and similarly prescribed in critically ill patients with or without cardiac history. Each additional unit was associated with a worse outcome with no evidence of differential effect due to cardiac history. Trial registration NL9049 (Dutch Trial Register), registered on 16 November 2020. Graphical Abstract
dc.fechaingreso.objetodigital2026-01-23
dc.format.extent12 páginas
dc.fuente.origenBiomed Central
dc.identifier.citationCritical Care. 2025 Dec 18;29(1):526
dc.identifier.doi10.1186/s13054-025-05745-5
dc.identifier.urihttps://doi.org/10.1186/s13054-025-05745-5
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/107851
dc.information.autorucEscuela de Medicina; Bakker, Jan; 0000-0003-2236-7391; 1044227
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaCritical Care
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.rights.licenseCC BY-NC-ND 4.0 Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectRed blood cell transfusion
dc.subjectIntensive care units
dc.subjectCritical care
dc.subjectHeart failure
dc.subject.ddc610
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAssociation between red blood cell transfusion and adverse clinical outcomes is Independent of cardiac history: a multicenter observational InPUT study analysis
dc.typeartículo
dc.volumen29
sipa.codpersvinculados1044227
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