Acute bronchodilator responsiveness in subjects with and without airflow obstruction in five Latin American cities: The PLATINO study

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dc.contributor.authorMontes de Oca, Maria
dc.contributor.authorPerez Padilla, Rogelio
dc.contributor.authorTalamo, Carlos
dc.contributor.authorHalbert, Ronald J.
dc.contributor.authorMoreno, Dolores
dc.contributor.authorVictorina Lopez, Maria
dc.contributor.authorMuino, Adriana
dc.contributor.authorJose Roberto, B. Jardim
dc.contributor.authorValdivia, Gonzalo
dc.contributor.authorPertuze, Julio
dc.contributor.authorAna Maria, B. Menezes
dc.contributor.authorPLATINO Team
dc.date.accessioned2024-01-10T13:10:52Z
dc.date.available2024-01-10T13:10:52Z
dc.date.issued2010
dc.description.abstractBackground: Acute bronchodilator responsiveness is an area of discussion in COPD. No information exists regarding this aspect of the disease from an unselected COPD population. We assessed acute bronchodilator responsiveness and factors influencing it in subjects with and without airway obstruction in an epidemiologic sample.
dc.description.abstractMethods: COPD was defined by GOLD criteria (post-bronchodilator FEV1/FVC <0.70). In this analysis, subjects with pre-bronchodilator FEV1/FVC <0.70 but >= 0.70 post-bronchodilator were considered to have reversible obstruction. Bronchodilator responsiveness after albuterol 200 mu g was assessed using three definitions: a) FVC and/or FEV1 increment >= 12% plus >= 200 mL over baseline; b) FEV1 >= 15% increase over baseline; and c) FEV1 increase >= 10% of predicted value.
dc.description.abstractResults: There were 756 healthy respiratory subjects, 48 1 subjects with reversible obstruction and 759 COPD subjects. Depending on the criterion used the proportion of person with acute bronchodilator responsiveness ranged between 15.0-28.2% in COPD, 11.4-21.6% in reversible obstructed and 2.7-7.2% in respiratory healthy. FEV1 changes were lower (110.6 +/- 7.40 vs. 164.7 +/- 11.8 mL) and FVC higher (146.5 +/- 14.2 mL vs. -131.0 +/- 19.6 mL) in COPD subjects compared with reversible obstructed. Substantial overlap in FEV1 and FVC changes was observed among the groups. Acute bronchodilator responsiveness in COPD persons was associated with less obstruction and never smoking.
dc.description.abstractConclusions: Over two-thirds of persons with COPD did not demonstrate acute bronchodilator responsiveness. The overall response was small and less than that considered as significant by ATS criteria. The overlap in FEV1, and FVC changes after bronchodilator among the groups makes it difficult to determine a threshold for separating them. (C) 2009 Elsevier Ltd. All rights reserved.
dc.description.funderAsociacion Latinoamericana de Torax (ALAT)
dc.description.funderBoehringer Ingelheim GmbH
dc.fechaingreso.objetodigital08-04-2024
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.pupt.2009.09.005
dc.identifier.issn1094-5539
dc.identifier.pubmedidMEDLINE:19818867
dc.identifier.urihttps://doi.org/10.1016/j.pupt.2009.09.005
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77952
dc.identifier.wosidWOS:000274968400005
dc.information.autorucMedicina;Pertuze J;S/I;99166
dc.information.autorucMedicina;Valdivia G;S/I;57007
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final35
dc.pagina.inicio29
dc.publisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
dc.revistaPULMONARY PHARMACOLOGY & THERAPEUTICS
dc.rightsacceso restringido
dc.subjectBronchodilator
dc.subjectChronic obstructive pulmonary disease
dc.subjectEpidemiology asthma/COPD
dc.subjectPrevalence
dc.subjectSPIROMETRIC REFERENCE VALUES
dc.subjectPULMONARY-DISEASE
dc.subjectREVERSIBILITY
dc.subjectDIAGNOSIS
dc.subjectASTHMA
dc.subjectFVC
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAcute bronchodilator responsiveness in subjects with and without airflow obstruction in five Latin American cities: The PLATINO study
dc.typeartículo
dc.volumen23
sipa.codpersvinculados99166
sipa.codpersvinculados57007
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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