Steroid Anti-Inflammatory Effects Did Not Improve Organ Quality in Brain-Dead Rats

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dc.article.number207534
dc.contributor.authorRebolledo Acevedo, Rolando Arturo
dc.contributor.authorLiu, Bo
dc.contributor.authorAkhtar, Mohammed Z.
dc.contributor.authorOttens, Petra J.
dc.contributor.authorZhang, Jian-Ning
dc.contributor.authorPloeg, Rutger J.
dc.contributor.authorLeuvenink, Henri G. D.
dc.date.accessioned2023-01-13T19:14:42Z
dc.date.available2023-01-13T19:14:42Z
dc.date.issued2015
dc.description.abstractEffect of glucocorticoid administration on improving the outcomes of kidney and liver allografts has not been clearly elucidated. This study investigated the effect of prednisolone administration after onset of brain death (BD) on kidney and liver in a controlled rat model of BD. BD was induced in rats by inflating an epidurally placed balloon catheter. Animals were treated with saline or prednisolone (5, 12.5, or 22.5 mg/kg) one hour after the onset of BD. After 4 hours of BD, experiments were terminated and serum and tissues were collected. Tissue gene and protein expression were measured for markers of inflammation, apoptosis, and cellular stress response markers. Prednisolone caused a reduction of plasma levels of IL-6, while the tissue expression of IL-6, IL-1β, and MCP-1 in both kidney and liver were also reduced. Creatinine plasma levels, complement (C3) expression, HSP-70, HO-1, Bcl2/BAX ratio, and PMN influx did not significantly change in kidney nor liver. Plasma AST and LDH levels were increased in the prednisolone treated group. Our results demonstrate prednisolone can has an anti-inflammatory effect mediated through reducing serum circulating cytokines. However, this anti-inflammatory effect does not translate into improved kidney function and indeed was associated with increased liver injury markers.
dc.format.extent10 páginas
dc.fuente.origenSIPA
dc.identifier.doi10.1155/2015/207534
dc.identifier.issn2314-6133
dc.identifier.urihttps://doi.org/10.1155/2015/207534
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/66304
dc.information.autorucEscuela de medicina ; Rebolledo Acevedo, Rolando Arturo ; 0000-0003-3501-4042 ; 127520
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final10
dc.pagina.inicio1
dc.revistaBioMed Research Internationales_ES
dc.rightsacceso abierto
dc.titleSteroid Anti-Inflammatory Effects Did Not Improve Organ Quality in Brain-Dead Ratses_ES
dc.typeartículo
dc.volumen2015
sipa.codpersvinculados127520
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