Maternal obesity and neonatal insulin resistance in the origin of metabolic syndrome in childhood

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dc.catalogadorpau
dc.contributor.authorFarías Jofré, Marcelo Enrique
dc.contributor.authorVillalobos Labra, Roberto Esteban
dc.contributor.authorSáez Pedraza, Pablo José
dc.contributor.authorWestermeier Lafuente, Francisco David
dc.contributor.authorPoblete Lizana, José Andrés
dc.contributor.authorKusanovic, Juan Pedro
dc.contributor.authorMardones S., Francisco
dc.contributor.authorSobrevía Luarte, Luis Alberto
dc.date.accessioned2023-07-10T20:37:48Z
dc.date.available2023-07-10T20:37:48Z
dc.date.issued2013
dc.description.abstractObesity during pregnancy has been recognized as an independent risk factor for maternal and fetal complications, including congenital anomalies, gestational diabetes mellitus, gestational hypertension and preeclampsia, caesarean delivery, macrosomia (birth weight > 4000 g), increased neonatal adiposity and hyperinsulinemia. In addition to perinatal complications associated to maternal obesity, rising epidemiological evidence has suggested the intrauterine programming of whole body insulin resistance (IR) in the offspring of obese pregnant woman, evaluated both at early neonatal stage and at young adulthood. Our cohort data showed association among elevated neonatal anthropometry measurements (birth weight and height) and increased levels of waist circumpherence and blood pressure in childohood, two components of the metabolic syndrome (MetS). In the other hand, the homeostasis model assesment index of insulin resistance (HOMA-IR) was correlated to the number of MetS components in this population. In order to describe potential mechanisms of relationship between maternal obesity and future development of MetS, we have evaluated modulators of neonatal insulin signaling pathway in human and animal models of maternal obesity. We have found increased levels of neonatal insulin secretion (serum C-peptide) and sub-clinical markers of cellular insulin resistance and endoplasmic reticulum stress (ER-stress) in offsprings of women with maternal weight excess. The ER stress response has been related to IR and diabetes mellitus development in multiple models of obesity. Thus, a mechanistic link could be proposed between maternal obesity, ER stress and IR in fetal tissues as part of the physiopathology route that connects abnormal intrauterine nutrition with elevated risk of MetS in childhood.
dc.fechaingreso.objetodigital2023-07-10
dc.format.extent1 página
dc.fuente.origenORCID
dc.identifier.doi10.1159/000354245
dc.identifier.issn0250-6807
dc.identifier.urihttps://doi.org/10.1159/000354245
dc.identifier.urihttps://publons.com/wos-op/publon/18766683/
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74153
dc.information.autorucEscuela de Medicina ; Farías Jofré, Marcelo Enrique ; 0000-0003-0473-2295 ; 12286
dc.information.autorucFacultad de Ciencias Biológicas ; Villalobos Labra, Roberto Esteban ; 0000-0002-9638-9721 ; 250107
dc.information.autorucFacultad de Ciencias Biológicas ; Sáez Pedraza, Pablo José ; 0000-0003-0521-9426 ; 132607
dc.information.autorucFacultad de Ciencias Biológicas ; Westermeier Lafuente, Francisco David ; 0000-0002-4476-4198 ; 181374
dc.information.autorucEscuela de Medicina ; Poblete Lizana, José Andrés ; 0000-0002-9778-6825 ; 80669
dc.information.autorucEscuela de Medicina ; Kusanovic, Juan Pedro ; 0000-0003-0640-2070 ; 1008900
dc.information.autorucEscuela de Medicina ; Mardones S., Francisco ; 0000-0002-0905-9493 ; 98805
dc.information.autorucEscuela de Medicina ; Sobrevía Luarte, Luis Alberto ; 0000-0001-5802-2243 ; 1002656
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final17
dc.pagina.inicio17
dc.relation.ispartofInternational Congress of Nutrition (20° ; 2008 ; Granada, Spain)
dc.revistaAnnals of Nutrition and Metabolism
dc.rightsacceso restringido
dc.subjectMaternal obesity
dc.subjectInsulin resistance
dc.subjectEr stress
dc.subjectMetabolic syndrome
dc.titleMaternal obesity and neonatal insulin resistance in the origin of metabolic syndrome in childhoodes_ES
dc.typecomunicación de congreso
dc.volumen63
sipa.codpersvinculados12286
sipa.codpersvinculados250107
sipa.codpersvinculados132607
sipa.codpersvinculados181374
sipa.codpersvinculados80669
sipa.codpersvinculados1008900
sipa.codpersvinculados98805
sipa.codpersvinculados1002656
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