Antiplatelet, anticoagulant, and fibrinolytic activity in vitro of extracts from selected fruits and vegetables

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dc.contributor.authorTorres Urrutia, Constanza
dc.contributor.authorGuzman, Luis
dc.contributor.authorSchmeda Hirschmann, Guillermo
dc.contributor.authorMoore Carrasco, Rodrigo
dc.contributor.authorAlarcon, Marcelo
dc.contributor.authorAstudillo, Luis
dc.contributor.authorGutierrez, Margarita
dc.contributor.authorCarrasco, Gilda
dc.contributor.authorYuri, Jose A.
dc.contributor.authorAranda, Eduardo
dc.contributor.authorPalomo, Ivan
dc.date.accessioned2024-01-10T13:45:58Z
dc.date.available2024-01-10T13:45:58Z
dc.date.issued2011
dc.description.abstractA diet rich in fruits and vegetables is known to decrease the risk of cardiovascular disease. However, the information regarding the antithrombotic activity (antiplatelet, anticoagulant, and fibrinolytic) of fruits and vegetables is scarce. The aim of this study was to assess the antithrombotic activity of extracts from fruits and vegetables widely consumed in central Chile. The study included samples of 19 fruits and 26 vegetables, representative of the local diet. The extracts prepared from each sample included an aqueous (juice or pressed solubles) and/or methanol-soluble fraction. The extracts were evaluated for antiplatelet, anticoagulant, and fibrinolytic activity in vitro at a final concentration of 1 mg/ml. The antiplatelet activity was assessed by platelet aggregation inhibition; anticoagulant activity was measured by the prothrombin time (PT), diluted prothrombin time (dPT), activated partial thromboplastin time (APTT), kaolin clotting time (KCT), and thrombin time. The fibrinolytic effect was determined with the euglobin clot lysis time and fibrin plate methods. Extracts of green beans and tomatoes inhibited platelet aggregation induced by ADP and arachidonic acid, in a concentration-dependent manner. The methanolic extracts of grapes prolonged the PT and dPT. Finally, extracts of raspberry prolonged the APTT and also presented fibrinolytic activity. In conclusion, from a screening that included a variety of fruits and vegetables, we found antiplatelet activity in green beans and tomatoes, anticoagulant activities in grapes and raspberries, whereas fibrinolytic activity was observed only in raspberries. Further investigations are necessary to advance in knowledge of the active compounds of these fruits and vegetables and their mechanisms of action. Blood Coagul Fibrinolysis 22:197-205 (c) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
dc.description.funderUniversidad de Talca, Chile
dc.fechaingreso.objetodigital2024-05-22
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1097/MBC.0b013e328343f7da
dc.identifier.eissn1473-5733
dc.identifier.issn0957-5235
dc.identifier.pubmedidMEDLINE:21311321
dc.identifier.urihttps://doi.org/10.1097/MBC.0b013e328343f7da
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79103
dc.identifier.wosidWOS:000289065600007
dc.information.autorucMedicina;Aranda E;S/I;102381
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final205
dc.pagina.inicio197
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaBLOOD COAGULATION & FIBRINOLYSIS
dc.rightsacceso restringido
dc.subjectPLATELET-AGGREGATION
dc.subjectTOMATO EXTRACT
dc.subjectCARDIOVASCULAR-DISEASE
dc.subjectRISK-FACTORS
dc.subjectONION
dc.subjectFLAVONOIDS
dc.subjectHEALTH
dc.subjectJUICE
dc.subjectCONSUMPTION
dc.subjectINHIBITION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAntiplatelet, anticoagulant, and fibrinolytic activity in vitro of extracts from selected fruits and vegetables
dc.typeartículo
dc.volumen22
sipa.codpersvinculados102381
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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