Corticosteroids use and risk of respiratory coinfections in mechanically ventilated patients with COVID-19

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dc.contributor.authorCeballos, María Elena
dc.contributor.authorNúñez Palma, Carolina Verónica
dc.contributor.authorUribe, Javier
dc.contributor.authorVera Alarcón, María Magdalena
dc.contributor.authorCastro López, Ricardo
dc.contributor.authorGarcía C., Patricia
dc.contributor.authorArriata, Gabriel
dc.contributor.authorGándara, Vicente
dc.contributor.authorVargas, Camila
dc.contributor.authorDomínguez De Landa, María Angélica
dc.contributor.authorCerón, Inés
dc.contributor.authorBorn, Pablo
dc.contributor.authorEspíndola, Eduardo
dc.date.accessioned2023-06-06T20:51:40Z
dc.date.available2023-06-06T20:51:40Z
dc.date.issued2021
dc.description.abstractBackground: To describe respiratory coinfections, predictive factors and outcomes in patients requiring mechanical ventilation (MV) with COVID-19. Methods: Cohort study, carried out in a Chilean single tertiary Hospital. All patients with COVID-19 admitted to ICU that required MV were included between 1 June and 31 July 2020 Results: 175 patients were admitted to ICU and required MV. Of these, 71 patients developed at least one respiratory coinfection (40.6 %). Early coinfections and late coinfections were diagnosed in 1.7% and 31.4% of all patients admitted to ICU respectively. Within late coinfections, 88% were bacterial, 10% were fungal, and 2% were viral coinfections. One third of isolated bacteria were multidrug-resistant. Multivariate analysis showed that the risk for coinfection was 7.7 times higher for patients with history of corticosteroids (adOR = 7.65, CI 95%: 1.04-56.2, p=0,046) and 2.7 times higher for patients that received dexamethasone during hospitalization (adOR=2.69; CI 95%: 1.14-6.35, p=0,024) than patients that were not exposed. For each additional day in MV, the risk of coinfection increases 1.1 times (adOR=1.06; CI 95%: 1.01-1.11, p=0,025)
dc.fechaingreso.objetodigital2023-06-06
dc.fuente.origenORCID
dc.identifier.doi10.21203/rs.3.rs-966047/v1
dc.identifier.urihttp://europepmc.org/abstract/PPR/PPR417067
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/70532
dc.information.autorucEscuela de medicina ; Ceballos, María Elena ; S/I ; 190187
dc.information.autorucEscuela de medicina ; Núñez Palma, Carolina Verónica ; S/I ; 195680
dc.information.autorucEscuela de medicina ; Vera Alarcón, María Magdalena ; 0000-0002-2969-3408 ; 226652
dc.information.autorucEscuela de medicina ; Castro López, Ricardo ; 0000-0002-0978-9891 ; 4537
dc.information.autorucEscuela de medicina ; García C., Patricia ; 0000-0002-3817-4896 ; 73909
dc.information.autorucEscuela de medicina ; Domínguez De Landa, María Angélica ; 0000-0001-7477-7574 ; 131798
dc.information.autorucEscuela de medicina ; Cerón, Inés ; S/I ; 9404
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final20
dc.pagina.inicio1
dc.revistaPreprint from Research Square
dc.rightsacceso restringido
dc.rights.licenseCreative Commons Attribution 4.0 International License
dc.subjectCoinfections
dc.subjectSecondary infections
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.subjectICU
dc.subjectMechanical ventilation
dc.titleCorticosteroids use and risk of respiratory coinfections in mechanically ventilated patients with COVID-19
dc.typepreprint
sipa.codpersvinculados190187
sipa.codpersvinculados195680
sipa.codpersvinculados226652
sipa.codpersvinculados4537
sipa.codpersvinculados73909
sipa.codpersvinculados131798
sipa.codpersvinculados9404
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