Pathological characteristics of thyroid microcarcinoma. A review of 402 biopsiesCaracterísticas de presentación del microcarcinoma papilar del tiroides. Experiencia retrospectiva de los últimos 12 años

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dc.article.number106217
dc.contributor.authorFardella B C.
dc.contributor.authorJiménez M M.
dc.contributor.authorMosso G L.
dc.contributor.authorGonzález V G.
dc.contributor.authorRodríguez P J.A.
dc.contributor.authorCampusano M C.
dc.contributor.authorLópez M J.M.
dc.contributor.authorArteaga U E.
dc.contributor.authorGonzález D H.
dc.contributor.authorLeón R A.
dc.contributor.authorGoñi E I.
dc.contributor.authorCruz O F.
dc.contributor.authorSolar G A.
dc.contributor.authorTorres M J.
dc.contributor.authorFardella B C.
dc.contributor.otherNCD Risk Factor Collaboration (NCD-RisC)
dc.date.accessioned2024-08-15T08:00:30Z
dc.date.available2024-08-15T08:00:30Z
dc.date.issued2005
dc.description.abstractBackground: Thyroid microcarcinoma is a tumor of 10 mm or less, that should have a low risk of mortality. However, a subgroup of these carcinomas is as aggressive as bigger tumors. Aim: To describe the pathological presentation of these tumors, and compare them with larger tumors. Material and methods: All pathological samples of thyroid carcinoma that were obtained between 1992 and 2003, were studied. In all biopsies, the pathological type, tumor size, the focal or multifocal character, the presence of lymph node involvement and the presence of lymphocytic thyroiditis or thyroid hyperplasia, were recorded. Results: One hundred eighteen microcarcinomas and 284 larger tumors were studied. The mean age of patients with microcarcinoma and larger tumors was 42.7±14 and 49.3±16 years respectively (p <0,001) and 83% were female, without gender differences between tumor types. Mean size of microcarcinomas was 8.6 mm and 116 (98%) were papillary carcinomas. Of these, 109 (94%) were well differentiated and seven (6%) were moderately differentiated. Thirty six (31%) were multifocal and in 10 (8,6%), there was lymph node involvement. The mean size of larger tumors was 23.8 mm and 241 (85%) were papillary carcinomas. Of these, 200 (83%) were well differentiated, and 41 (17%) were moderately differentiated. Eighty five (35%) were multifocal and in 44 (18%) there was lymph node involvement. The prevalence of thyroiditis and hyperplasia was significantly higher among microcarcinomas than in larger tumors (15 and 2.5%, respectively, p <0.001, for the former; 32.4 and 1.7%, respectively, p <0.001, for the latter). Conclusions: In this series, one third of microcarcinomas were multifocal and 10% had lymph node involvement. Therefore, the aggressiveness of these tumors is higher than what is reported in the literature and they should be treated with total thyroidectomy.
dc.description.funderANID through FONDECYT
dc.format.extent4 páginas
dc.fuente.origenScopus
dc.identifier.doi10.1161/01.HYP.0000079505.25750.11
dc.identifier.eissn07176163
dc.identifier.issn00349887
dc.identifier.pubmedid16446853
dc.identifier.scopusidSCOPUS_ID:31144471868
dc.identifier.urihttps://doi.org/10.1161/01.HYP.0000079505.25750.11
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87482
dc.identifier.wosidWOS:000228990600008
dc.information.autorucFacultad de Medicina; Mosso Gomez, Lorena Montserrat; S/I; 88201
dc.issue.numero3
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final1310
dc.pagina.inicio1305
dc.relation.ispartof14th European Meeting on Hypertension, JUN 13-17, 2004, Paris, FRANCE
dc.revistaRevista Medica de Chile
dc.rightsregistro bibliográfico
dc.subjectNeoplasms, glandular and epithelial
dc.subjectThyroid neoplasms
dc.subjectThyroidectomy
dc.subject.ddc550
dc.subject.deweyCiencias de la tierraes_ES
dc.titlePathological characteristics of thyroid microcarcinoma. A review of 402 biopsiesCaracterísticas de presentación del microcarcinoma papilar del tiroides. Experiencia retrospectiva de los últimos 12 años
dc.typeartículo
dc.volumen133
sipa.codpersvinculados88201
sipa.indexScopus
sipa.indexPubmed
sipa.trazabilidadCarga WOS-SCOPUS;15-08-2024
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