Medical and Surgical Treatments for Obesity Have Opposite Effects on Peptide YY and Appetite: A Prospective Study Controlled for Weight Loss

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dc.contributor.authorValderas, Juan P.
dc.contributor.authorIrribarra, Veronica
dc.contributor.authorBoza, Camilo
dc.contributor.authorde la Cruz, Rolando
dc.contributor.authorLiberona, Yessica
dc.contributor.authorMaria Acosta, Ana
dc.contributor.authorYolito, Macarena
dc.contributor.authorMaiz, Alberto
dc.date.accessioned2024-01-10T13:50:24Z
dc.date.available2024-01-10T13:50:24Z
dc.date.issued2010
dc.description.abstractContext: The effects of medical and surgical treatments for obesity on peptide YY (PYY) levels, in patients with similar weight loss, remain unclear.
dc.description.abstractObjective: The objective of the study was to assess PYY and appetite before and after Roux-en-Y gastric bypass (RYGB), sleeve gastrectomy (SG), and medical treatment (MED).
dc.description.abstractDesign: This was a prospective, controlled, nonrandomized study.
dc.description.abstractSetting: The study was conducted at the Departments of Nutrition and Digestive Surgery at a university hospital.
dc.description.abstractParticipants: Participants included three groups of eight patients with similar body mass indexes (RYGB 37.8 +/- 0.8, SG 35.3 +/- 0.7, and MED 39.1 +/- 1.7 kg/m(2), P = NS) and eight lean controls (body mass index 21.7 +/- 0.7 kg/m(2)).
dc.description.abstractMain Outcome Measures: Total plasma PYY, hunger, and satiety visual analog scales in fasting and after ingestion of a standard test meal were measured.
dc.description.abstractResults: At baseline there were no differences in the area under the curve (AUC) of PYY, hunger, or satiety in obese groups. Two months after the interventions, RYGB, SG, and MED groups achieved similar weight loss (17.7 +/- 3, 14.9 +/- 2.4, 16.6 +/- 4%, respectively, P = NS). PYY AUC increased in RYGB (P < 0.001) and SG (P < 0.05) and did not change in MED. PYY levels decreased at fasting, 30 min, and 180 min after a standard test meal in MED(P < 0.05). Hunger AUC decreased in RYGB (P < 0.05). Satiety AUC increased in RYGB (P < 0.05) and SG (P < 0.05). Appetite did not change in MED. PYY AUC correlated with satiety AUC (r = 0.35, P < 0.05).
dc.description.abstractConclusion: RYGB and SG increased PYY and reduced appetite. MED failed to produce changes. Different effects occur despite similar weight loss. This suggests that the weight-loss effects of these procedures are enhanced by an increase in PYY and satiety. (J Clin Endocrinol Metab 95: 1069-1075, 2010)
dc.description.funderDepartment of Nutrition, Diabetes, and Metabolism, School of Medicine, Pontificia Universidad Catolica de Chile
dc.fechaingreso.objetodigital2024-05-15
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1210/jc.2009-0983
dc.identifier.eissn1945-7197
dc.identifier.issn0021-972X
dc.identifier.pubmedidMEDLINE:20097707
dc.identifier.urihttps://doi.org/10.1210/jc.2009-0983
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79528
dc.identifier.wosidWOS:000275197500011
dc.information.autorucMedicina;Acosta AM;S/I;115472
dc.information.autorucMedicina;Boza C;S/I;761
dc.information.autorucMedicina;De la Cruz R;S/I;119
dc.information.autorucMedicina;Irribarra V;S/I;366
dc.information.autorucMedicina;Liberona Y;S/I;151551
dc.information.autorucMedicina;Maiz A;S/I;23935
dc.information.autorucMedicina;Valderas JP;S/I;90059
dc.information.autorucMedicina;Yolito M;S/I;174377
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1075
dc.pagina.inicio1069
dc.publisherENDOCRINE SOC
dc.revistaJOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
dc.rightsacceso restringido
dc.subjectGASTRIC BYPASS-SURGERY
dc.subjectGLUCAGON-LIKE PEPTIDE-1
dc.subjectGUT HORMONE
dc.subjectSLEEVE GASTRECTOMY
dc.subjectBILIOPANCREATIC DIVERSION
dc.subjectPOSTPRANDIAL GHRELIN
dc.subjectCIRCULATING LEVELS
dc.subjectPLASMA GHRELIN
dc.subjectEXERCISE
dc.subjectHOMEOSTASIS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMedical and Surgical Treatments for Obesity Have Opposite Effects on Peptide YY and Appetite: A Prospective Study Controlled for Weight Loss
dc.typeartículo
dc.volumen95
sipa.codpersvinculados115472
sipa.codpersvinculados761
sipa.codpersvinculados119
sipa.codpersvinculados366
sipa.codpersvinculados151551
sipa.codpersvinculados23935
sipa.codpersvinculados90059
sipa.codpersvinculados174377
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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