Synthesis and in vitro antiprotozoal activity of thiophene ring-containing quinones

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dc.contributor.authorValderrama, J
dc.contributor.authorFournet, A
dc.contributor.authorValderrama, C
dc.contributor.authorBastias, S
dc.contributor.authorAstudillo, C
dc.contributor.authorde Arias, AR
dc.contributor.authorInchausti, A
dc.contributor.authorYaluff, G
dc.date.accessioned2024-01-10T12:43:18Z
dc.date.available2024-01-10T12:43:18Z
dc.date.issued1999
dc.description.abstractA series of quinones (3a-i, 4-9, 11) and aromatic compounds (2a, 2d, 2g) containing the thiophene ring were tested in vitro against the trypomastigote form of Trypanosoma cruzi and the promastigote forms of Leishmania. The quinones 3a-i, 4, 5a, b, 6 and 9 having the thiophene ring fused to a quinone nucleus were the most active members of the series. The electron affinities of the benzo[b]thiophene-4,7-quinones 3, evaluated by their LUMO energies and halfwave potentials, are reported.
dc.fechaingreso.objetodigital2024-07-09
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1248/cpb.47.1221
dc.identifier.issn0009-2363
dc.identifier.pubmedidMEDLINE:10517004
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77583
dc.identifier.wosidWOS:000082671300003
dc.information.autorucQuímica;Valderrama J;S/I;98772
dc.issue.numero9
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final1226
dc.pagina.inicio1221
dc.publisherPHARMACEUTICAL SOC JAPAN
dc.revistaCHEMICAL & PHARMACEUTICAL BULLETIN
dc.rightsacceso abierto
dc.subjectbenzo[b]thiophene-4,7-quinones
dc.subjectsynthesis
dc.subjectbiological activity
dc.subjectLeishmania
dc.subjectTrypanosoma cruzi
dc.subjectelectron affinity
dc.subjectLEISHMANIASIS
dc.subjectCHEMOTHERAPY
dc.subjectANALOGS
dc.subjectDRUGS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSynthesis and in vitro antiprotozoal activity of thiophene ring-containing quinones
dc.typeartículo
dc.volumen47
sipa.codpersvinculados98772
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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