Multicriteria optimal design of emamectin benzoate microparticles obtained by spray drying and ionic gelation

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dc.article.number738638
dc.catalogadorpau
dc.contributor.authorMolina V.
dc.contributor.authorFranco W.
dc.contributor.authorPerez-Correa J.R.
dc.contributor.authorBenavides S.
dc.contributor.authorTroncoso J.M.
dc.contributor.authorRobert P.
dc.contributor.authorLuna R.
dc.contributor.authorvon Plessing C.
dc.date.accessioned2023-08-07T12:57:52Z
dc.date.available2023-08-07T12:57:52Z
dc.date.issued2022
dc.description.abstract© 2022 Elsevier B.V.Emamectin benzoate (EB) is an antiparasitic used to control Caligus rogercresseyi in Chile. However, it has lost efficacy, and the parasite has been exposed to a sublethal dose. Microencapsulation has been suggested as an alternative method to protect and control the release of poorly absorbed drugs to ensure their lethal doses. Accordingly, design of experiments (DOE) and response surface methodology (RSM) were applied to find optimal conditions for EB's ionic gelation (IG) and spray drying (SD) microencapsulation. We used multiobjective (MOO) and multi-response optimization techniques as the desirability function (DFA) to obtain optimal conditions that produce microparticles that satisfy several criteria, such as low gastric digestion (GD) and high yield (Y), encapsulation efficiency (EE), load capacity (LC), and intestinal digestion (ID). The optimization process prioritized the digestion responses and was constrained according to a mass balance. MOO generated theoretical solutions that were better than any of the DOE experimental solutions. Both optimization methods achieved a more balanced performance than the responses obtained in the experimental design. Each optimization method produced better experimental responses than the other in some responses. In SD, DFA yielded higher LC, GD, and ID than MOO by 7.5%, 9.3%, and 2.1%, respectively. In contrast, MOO obtained higher Y and EE than DFA by 6.2% and 10.1%, respectively. In IG, the DFA method yielded a solution with better responses than MOO in LC (3.7%), GD (7.4%), and ID (3.2%), while the MOO solution was better in Y (14.2%) and EE (19.3%). Both multicriteria optimization techniques were suitable for obtaining optimal solutions; however, neither proved superior in all cases.
dc.fechaingreso.objetodigital2023-08-07
dc.fuente.origenSCOPUS
dc.identifier.doi10.1016/j.aquaculture.2022.738638
dc.identifier.issn00448486
dc.identifier.scopusidSCOPUS_ID:85135421455
dc.identifier.urihttp://www.journals.elsevier.com/aquaculture/
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74361
dc.information.autorucFacultad de Ingeniería ; Villalobos Molina Victoria Andrea ; 0000-0002-3725-3963 ; 1122842
dc.information.autorucEscuela de Ingeniería ; Franco Melazzini Wendy Veronica ; 0000-0001-5858-8554 ; 219464
dc.information.autorucEscuela de Ingeniería ; Perez Correa Jose Ricardo ; 0000-0002-1278-7782 ; 100130
dc.language.isoen
dc.nota.accesoContenido parcial
dc.publisherElsevier B.V.
dc.relation.ispartofAquaculture
dc.revistaAquaculture
dc.subjectDesirability function
dc.subjectEmamectin benzoate
dc.subjectIonic gelation
dc.subjectSpray drying
dc.subjectTOPSIS
dc.subjectTSEMO
dc.titleMulticriteria optimal design of emamectin benzoate microparticles obtained by spray drying and ionic gelation
dc.typeartículo
dc.volumen561
sipa.codpersvinculados1122842
sipa.codpersvinculados219464
sipa.codpersvinculados100130
sipa.indexSCOPUS
sipa.trazabilidadSCOPUS;10-11-2022
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