Anti phospholipid antibodies in Chilean patients with systemic lupus erythematosus

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dc.contributor.authorPalomo, I
dc.contributor.authorPereira, J
dc.contributor.authorAlarcon, M
dc.contributor.authorLarrain, AM
dc.contributor.authorPinochet, C
dc.contributor.authorVasquez, M
dc.contributor.authorVelez, MT
dc.contributor.authorLeon, M
dc.contributor.authorEspinola, R
dc.contributor.authorPierangeli, S
dc.date.accessioned2025-01-21T01:10:18Z
dc.date.available2025-01-21T01:10:18Z
dc.date.issued2002
dc.description.abstractAntiphospholipid antibodies (aPLs) are a heterogeneous family of antibodies found in autoimmune disorders, infectious diseases, and other situations. The presence of different aPLs has been associated with various clinical manifestations of the antiphospholipid syndrome (APS). The objective of this study was to investigate the prevalence of aPLs in a group of 90 Chilean patients with systemic lupus erytematosus (SLE) and 90 healthy controls. We measured anticardiolipin antibodies (aCLs), antiphosphatidylserine antibodies (aPSs), anti-beta(2) glycoprotein I antibodies (anti-beta(2)GPIs), and antiprothrombin antibodies (aPTs) with an enzyme-linked immunosorbent technique using "in-house" assays. Fifty-four of 90 SLE patients (60.0%) had some type of aPL. Forty of 90 (44.4%) were positive for aCLs, 9 of 61 (14.8%) had aPSs, 21 of 90 (23.3%) had anti-beta(2)GPIs, and 18 of 90 (20.0%) had aPTs. In the control group, prevalences were as follows: aCLs, 3.3%; aPSs, 1.1%; anti-beta2GPIs, 1.1%; aPTs, 2.2%. In most cases, values were in the low-positive range. Of all aPL detected, 29.5% was of the IgG isotype, 37.5% IgM, and 33.0% IgA. We observed a correlation between aCLs and aPSs and of these antibodies with anti-beta(2)GPIs and aPTs but not between anti-beta2GPIs and aPTs. Our results show a high prevalence of aPLs in SLE patients. An association between different specificities and isotypes of aPLs was also observed.
dc.fuente.origenWOS
dc.identifier.doi10.1067/mlc.2002.128467
dc.identifier.issn0022-2143
dc.identifier.urihttps://doi.org/10.1067/mlc.2002.128467
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96671
dc.identifier.wosidWOS:000179442600006
dc.issue.numero5
dc.language.isoen
dc.pagina.final341
dc.pagina.inicio336
dc.revistaJournal of laboratory and clinical medicine
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAnti phospholipid antibodies in Chilean patients with systemic lupus erythematosus
dc.typeartículo
dc.volumen140
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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