Platelet activation in chronic cocaine users: Effect of short term abstinence

Simple item page
dc.contributor.authorPereira, Jaime
dc.contributor.authorSaez, Claudia G.
dc.contributor.authorPallavicini, Julio
dc.contributor.authorPanes, Olga
dc.contributor.authorPereira Flores, Karla
dc.contributor.authorCabreras, Manuel J.
dc.contributor.authorMassardo, Teresa
dc.contributor.authorMezzano, Diego
dc.date.accessioned2024-01-10T12:41:30Z
dc.date.available2024-01-10T12:41:30Z
dc.date.issued2011
dc.description.abstractCocaine abuse increases the risk of cardiac and cerebrovascular events, such as myocardial infarction and ischemic stroke. The underlying mechanisms leading to these complications are not fully understood although intravascular thrombus formation has been observed. The aim of this study was to investigate the existence of platelet activation and the effect of short-term abstinence in chronic cocaine consumers. We studied 23 cocaine dependent individuals (aged 20-54 years) who met DSM-IV criteria for cocaine dependence and 20 controls. Samples were obtained at baseline, within 72 h of last drug exposure and after 4 weeks of controlled abstinence. Monocyte-platelet aggregates (MPA) were measured by flow cytometry. Plasma levels of soluble CD40L (sCD40L), Neutrophil-Activating Peptide-2 (NAP-2) and regulated on activation normal T cells expressed and secreted (RANTES) were determined by ELISA. Levels of MPA, sCD40L, NAP-2 and RANTES were significantly higher (all p < 0.05) in cocaine addicts compared to controls at baseline. All the parameters returned to values similar to the control group after 4-weeks' abstinence. Levels of sCD40L and RANTES were associated with an index of intensity of drug consumption (p < 0.02). Our results demonstrate that cocaine use induces platelet activation which is a prominent finding after recent consumption. The persistence over time of this condition may contribute not only to acute thrombotic complications but also to the development of early-onset atherosclerotic process observed in cocaine abusers.
dc.description.funderFONDECYT (Fondo de Desarrollo Cientifico y Tecnologico, Ministry of Education of Chile)
dc.fechaingreso.objetodigital2024-05-23
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3109/09537104.2011.578181
dc.identifier.eissn1369-1635
dc.identifier.issn0953-7104
dc.identifier.pubmedidMEDLINE:21806491
dc.identifier.urihttps://doi.org/10.3109/09537104.2011.578181
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77423
dc.identifier.wosidWOS:000296504400006
dc.information.autorucMedicina;Cabreras M;S/I;148933
dc.information.autorucMedicina;Mezzano D ;S/I;99455
dc.information.autorucMedicina;Panes O ;S/I;90271
dc.information.autorucMedicina;Pereira J ;S/I;99371
dc.information.autorucIngeniería;Pereira K;S/I;132641
dc.information.autorucMedicina;Saez C;S/I;102375
dc.issue.numero8
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final601
dc.pagina.inicio596
dc.publisherTAYLOR & FRANCIS INC
dc.revistaPLATELETS
dc.rightsacceso restringido
dc.subjectplatelet activation
dc.subjectcocaine
dc.subjectatherosclrosis
dc.subjectplatelet chemokines
dc.subjectATHEROSCLEROSIS
dc.subjectINFLAMMATION
dc.subjectEXPRESSION
dc.subjectCHEMOKINES
dc.subjectARTERY
dc.subjectDEATH
dc.subjectSCALE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePlatelet activation in chronic cocaine users: Effect of short term abstinence
dc.typeartículo
dc.volumen22
sipa.codpersvinculados148933
sipa.codpersvinculados99455
sipa.codpersvinculados90271
sipa.codpersvinculados99371
sipa.codpersvinculados132641
sipa.codpersvinculados102375
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2024-05-23. Platelet activation in chronic cocaine users - Effect of short term abstinence.pdf
Size:
3.16 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas