Gingival Wound Healing: An Essential Response Disturbed by Aging?

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dc.contributor.authorSmith, P. C.
dc.contributor.authorCaceres, M.
dc.contributor.authorMartinez, C.
dc.contributor.authorOyarzun, A.
dc.contributor.authorMartinez, J.
dc.date.accessioned2019-10-16T20:16:10Z
dc.date.available2019-10-16T20:16:10Z
dc.date.issued2015
dc.description.abstractGingival wound healing comprises a series of sequential responses that allow the closure of breaches in the masticatory mucosa. This process is of critical importance to prevent the invasion of microbes or other agents into tissues, avoiding the establishment of a chronic infection. Wound healing may also play an important role during cell and tissue reaction to long-term injury, as it may occur during inflammatory responses and cancer. Recent experimental data have shown that gingival wound healing is severely affected by the aging process. These defects may alter distinct phases of the wound-healing process, including epithelial migration, granulation tissue formation, and tissue remodeling. The cellular and molecular defects that may explain these deficiencies include several biological responses such as an increased inflammatory response, altered integrin signaling, reduced growth factor activity, decreased cell proliferation, diminished angiogenesis, reduced collagen synthesis, augmented collagen remodeling, and deterioration of the proliferative and differentiation potential of stem cells. In this review, we explore the cellular and molecular basis of these defects and their possible clinical implications.
dc.format.extent8 páginas
dc.fuente.origenFacultad de Medicina
dc.identifier.doi10.1177/0022034514563750
dc.identifier.issn0022-0345
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/26566
dc.issue.numeroNo. 3
dc.language.isoen
dc.pagina.final402
dc.pagina.inicio395
dc.revistaJournal of Dental Researches_ES
dc.subjectgingivaes_ES
dc.subjectgerontologyes_ES
dc.subjectcell biologyes_ES
dc.subjectmyofibroblastes_ES
dc.subjectextracellular matrixes_ES
dc.subjectcytokineses_ES
dc.subjectperiodontal-ligament cellses_ES
dc.subjectage-related-changeses_ES
dc.subjecthuman fibroblastses_ES
dc.subjectextracellular-matrixes_ES
dc.subjectcollagen phagocytosises_ES
dc.subjectcellular senescencees_ES
dc.subjectstem-cellses_ES
dc.subjecttissuees_ES
dc.subjectexpressiones_ES
dc.subjectangiogenesises_ES
dc.subjectDentistry, Oral Surgery & Medicinees_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleGingival Wound Healing: An Essential Response Disturbed by Aging?es_ES
dc.typeartículo
dc.volumenVol. 94
sipa.codpersvinculados1006488
sipa.codpersvinculados1008613
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