An RCT of a decision aid to support informed choices about taking aspirin to prevent colorectal cancer and other chronic diseases: a study protocol for the SITA (Should I Take Aspirin?) trial

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dc.contributor.authorMilton, Shakira
dc.contributor.authorMcIntosh, Jennifer
dc.contributor.authorMacrae, Finlay
dc.contributor.authorChondros, Patty
dc.contributor.authorTrevena, Lyndal
dc.contributor.authorJenkins, Mark
dc.contributor.authorWalter, Fiona M.
dc.contributor.authorTaylor, Natalie
dc.contributor.authorBoyd, Lucy
dc.contributor.authorMartínez Gutiérrez, Javiera
dc.date.accessioned2021-07-19T16:52:51Z
dc.date.available2021-07-19T16:52:51Z
dc.date.issued2021
dc.date.updated2021-07-18T00:02:12Z
dc.description.abstractAbstract Background Australian guidelines recommend that all people aged 50–70 years old actively consider taking daily low-dose aspirin (100–300 mg per day) for 2.5 to 5 years to reduce their risk of colorectal cancer (CRC). Despite the change of national CRC prevention guidelines, there has been no active implementation of the guidelines into clinical practice. We aim to test the efficacy of a health consultation and decision aid, using a novel expected frequency tree (EFT) to present the benefits and harms of low dose aspirin prior to a general practice consultation with patients aged 50–70 years, on informed decision-making and uptake of aspirin. Methods Approximately five to seven general practices in Victoria, Australia, will be recruited to participate. Patients 50–70 years old, attending an appointment with their general practitioner (GP) for any reason, will be invited to participate in the trial. Two hundred fifty-eight eligible participants will be randomly allocated 1:1 to intervention or active control arms using a computer-generated allocation sequence stratified by general practice, sex, and mode of trial delivery (face-to-face or teletrial). There are two co-primary outcomes: informed decision-making at 1-month post randomisation, measured by the Multi-dimensional Measure of Informed Choice (MMIC), and self-reported daily use of aspirin at 6 months. Secondary outcomes include decisional conflict at 1-month and other behavioural changes to reduce CRC risk at both time points. Discussion This trial will test the efficacy of novel methods for implementing national guidelines to support informed decision-making about taking aspirin in 50–70-year-olds to reduce the risk of CRC and other chronic diseases. Trial registration The Australian New Zealand Clinical Trials Registry (ANZCTR) ACTRN12620001003965 . Registered on 10 October 2020.
dc.format.extent17 páginas
dc.fuente.origenAutoarchivo
dc.identifier.citationTrials. 2021 Jul 15;22(1):452
dc.identifier.doi10.1186/s13063-021-05365-8
dc.identifier.urihttps://doi.org/10.1186/s13063-021-05365-8
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/60997
dc.information.autorucEscuela de Medicina ; Martínez Gutiérrez, Javiera ; 0000-0002-2493-9974 ; 18421
dc.issue.numeroNo. 452
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final17
dc.pagina.inicio1
dc.revistaTrialses_ES
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.subjectPreventive medicinees_ES
dc.subjectGeneral practicees_ES
dc.subjectPrimary carees_ES
dc.subjectCancer preventiones_ES
dc.subjectBowel canceres_ES
dc.subjectColorectal canceres_ES
dc.subjectAspirines_ES
dc.subjectGuideline implementationes_ES
dc.subjectChemopreventiones_ES
dc.subjectDecision aides_ES
dc.subjectInformed decision makinges_ES
dc.subject.ddc614
dc.subject.deweyMedicina y saludes_ES
dc.titleAn RCT of a decision aid to support informed choices about taking aspirin to prevent colorectal cancer and other chronic diseases: a study protocol for the SITA (Should I Take Aspirin?) triales_ES
dc.typeartículo
dc.volumenVol. 22
sipa.codpersvinculados18421
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