Nitrous oxide (N2O) reduces postoperative opioid-induced hyperalgesia after remifentanil-propofol anaesthesia in humans

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dc.contributor.authorEchevarria, G.
dc.contributor.authorElgueta, F.
dc.contributor.authorFierro, C.
dc.contributor.authorBugedo, D.
dc.contributor.authorFaba, G.
dc.contributor.authorIniguez Cuadra, R.
dc.contributor.authorMunoz, H. R.
dc.contributor.authorCortinez, L. I.
dc.date.accessioned2024-01-10T12:06:57Z
dc.date.available2024-01-10T12:06:57Z
dc.date.issued2011
dc.description.abstractBackground. The aim of this study was to test if intraoperative administration of N2O during propofol-remifentanil anaesthesia prevented the onset of postoperative opioid-induced hyperalgesia(OIH).
dc.description.abstractMethods. Fifty adult ASA I-II patients undergoing elective open septorhinoplasty under general anaesthesia were studied. Anaesthesia was with propofol, adjusted to bispectral index (40-50), and remifentanil (0.30 mu g kg(-1) min(-1)). Patients were assigned to one of the two groups: with N2O (70%) and without N2O (100% oxygen). Mechanical pain thresholds were measured before surgery and 2 and 12-18 h after surgery. Pain measurements were performed on the arm using hand-held von Frey filaments. A non-parametric analysis of variance was used in the von Frey data analysis. P<0.05 was considered statistically significant.
dc.description.abstractResults. Baseline pain thresholds to mechanical stimuli were similar in both groups, with mean values of 69 [95% confidence interval (CI): 50.2, 95.1] g in the group without N2O and 71 (95% CI: 45.7, 112.1) g in the group with N2O. Postoperative pain scores and cumulative morphine consumption were similar between the groups. The analysis revealed a decrease in the threshold value in both groups. However, post hoc comparisons showed that at 12-18 h after surgery, the decrease in mechanical threshold was greater in the group without N2O than the group with N2O (post hoc analysis with Bonferroni's correction, P<0.05).
dc.description.abstractConclusions. Intraoperative 70% N2O administration significantly reduced postoperative OIH in patients receiving propofol-remifentanil anaesthesia.
dc.fechaingreso.objetodigital2024-04-30
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1093/bja/aer323
dc.identifier.issn0007-0912
dc.identifier.pubmedidMEDLINE:21965050
dc.identifier.urihttps://doi.org/10.1093/bja/aer323
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76227
dc.identifier.wosidWOS:000297152800016
dc.information.autorucMedicina;Cortínez L;S/I;79356
dc.information.autorucMedicina;Faba G;S/I;2401
dc.information.autorucMedicina;Iñiguez R;S/I;7904
dc.information.autorucMedicina;Muñoz H;S/I;73573
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final965
dc.pagina.inicio959
dc.publisherOXFORD UNIV PRESS
dc.revistaBRITISH JOURNAL OF ANAESTHESIA
dc.rightsacceso restringido
dc.subjectanalgesia, postoperative
dc.subjectanalgesics opioid
dc.subjecthyperalgesia
dc.subjectnitrous oxide
dc.subjectremifentanil
dc.subjectSPINAL DORSAL-HORN
dc.subjectPOSTINFUSION HYPERALGESIA
dc.subjectANTIHYPERALGESIC PROPERTIES
dc.subjectINDUCED ANALGESIA
dc.subjectPAIN
dc.subjectTOLERANCE
dc.subjectMODULATION
dc.subjectKETAMINE
dc.subjectSURGERY
dc.subjectRATS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNitrous oxide (N2O) reduces postoperative opioid-induced hyperalgesia after remifentanil-propofol anaesthesia in humans
dc.typeartículo
dc.volumen107
sipa.codpersvinculados79356
sipa.codpersvinculados2401
sipa.codpersvinculados7904
sipa.codpersvinculados73573
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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