The paradoxical response of growth hormone (GH) to thyrotropin-releasing hormone (TRH) in constitutionally tall children involves a cholinergic pathway

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dc.contributor.authorArteaga U., Eugenio
dc.contributor.authorValenzuela, P.
dc.contributor.authorCattani Ortega, Andreina
dc.contributor.authorValle de la Cortina, María Angélica del
dc.date.accessioned2019-12-28T02:45:12Z
dc.date.available2019-12-28T02:45:12Z
dc.date.issued1989
dc.description.abstractTo investigate whether or not a cholinergic pathway is involved in the paradoxical response of GH to TRH in constitutionally tall children, we studied 8 healthy prepubertal children aged $4^{2}/{_{_{12}}} - 7^{10}/{_{_{12}}} {? yr}$, whose heights were over the 95th percentile of the NCHS tables. We defined as ?paradoxical? a GH increment greater than 5 ng/ml in response to TRH. Five out of 8 children showed a paradoxical response of GH to TRH (mean GH peak after TRH of 10.7 ? 1.1 ng/ml). Pretreatment with atropine (0.01 mg/kg IM 30 min prior to the TRH administration) abolished the TRH induced GH rise (peak GH after TRH of 1.5 ? 1.0 ng/ml, p < 0.01) but did not modify the TSH response (peak TSH after TRH: basal conditions 8.7 ? 0.8 ?U/ml, post atropine: 9.5 ? 1.4 ?U/ml, p > 0.05). Our results demonstrate that a cholinergic pathway is involved in the paradoxical response of GH to TRH in constitutionally tall children.
dc.format.extent5 páginas
dc.fuente.origenSpringer
dc.identifier.doi10.1007/BF03350756
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/27061
dc.identifier.urihttp://link.springer.com/article/10.1007/BF03350756
dc.issue.numeroNo. 8
dc.language.isoen
dc.pagina.final548
dc.pagina.inicio543
dc.revistaJournal of Endocrinological Investigationes_ES
dc.rightsacceso restringido
dc.subjectGrowth Hormonees_ES
dc.subjectThyrotropin-Releasing-Hormonees_ES
dc.subjectCholinergic Athwayes_ES
dc.subjectAtropinees_ES
dc.subjectTall staturees_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherHormona del crecimientoes_ES
dc.subject.otherHormona Liberadora de Tirotropinaes_ES
dc.subject.otherAtropinaes_ES
dc.titleThe paradoxical response of growth hormone (GH) to thyrotropin-releasing hormone (TRH) in constitutionally tall children involves a cholinergic pathwayes_ES
dc.typeartículo
dc.volumenVol. 12
sipa.codpersvinculados98586
sipa.codpersvinculados60674
sipa.codpersvinculados99178
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