Trasplante hepático: Evolución, curva de aprendizaje y resultados después de los primeros 300 casos

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dc.catalogadorgrr
dc.contributor.advisorGuerra Castro, Juan Francisco
dc.contributor.authorQuezada González, José Luis
dc.contributor.authorCancino, Alejandra
dc.contributor.authorArrese Jimenez, Marco Antonio
dc.contributor.authorWolff, Rodrigo
dc.contributor.authorBenitez Gajardo, Carlos Esteban
dc.contributor.authorPattillo Silva, Juan Carlos
dc.contributor.authorGana Ansaldo, Juan Cristobal
dc.contributor.authorConcha Pinto, Mario Rodrigo
dc.contributor.authorCortinez Fernandez, Luis Ignacio
dc.contributor.authorVera Alarcón, María Magdalena
dc.contributor.authorMiranda, Paula
dc.contributor.authorRubilar, Francisco
dc.contributor.authorTroncoso, Andrés
dc.contributor.authorBriceno Valenzuela, Eduardo Andres
dc.contributor.authorDib Marambio, Martin Javier
dc.contributor.authorJarufe Cassis, Nicolas Patricio
dc.contributor.authorMartínez, Jorge
dc.date.accessioned2024-06-12T03:21:31Z
dc.date.available2024-06-12T03:21:31Z
dc.date.issued2019
dc.description.abstractLiver transplantation (LT) is an option for people with liverfailure who cannot be cured with other therapies and for some people with liver cancer. Aim: To describe, and analyze the first 300 LT clinical results, andto establish our learning curve. Material and Methods: Retrospective cohortstudy with data obtained from a prospectively collected LT Program database.We included all LT performed at a single center from March 1994 to September2017. The database gathered demographics, diagnosis, indications for LT, surgicalaspects and postoperative courses. We constructed a cumulative summation testfor learning curve (LC-CUSUM) using 30-day post-LT mortality. Mortality at 30days, and actuarial 1-, and 5-year survival rate were analyzed. Results: A total of281 patients aged 54 (0-71) years (129 women) underwent 300 LT. Ten percentof patients were younger than 18 years old. The first, second and third indicationsfor LT were non-alcoholic steatohepatitis, chronic autoimmune hepatitis andalcoholic liver cirrhosis, respectively. Acute liver failure was the LT indication in51 cases (17%). The overall complication rate was 71%. Infectious and biliarycomplications were the most common of them (47 and 31% respectively). TheLC-CUSUM curve shows that the first 30 patients corresponded to the learningcurve. The peri-operative mortality was 8%. Actuarial 1 and 5-year survival rateswere 82 and 71.4%, respectively. Conclusions: Outcome improvement of a LTprogram depends on the accumulation of experience after the first 30 transplantsand the peri-operative mortality directly impacted long-term survival.
dc.fechaingreso.objetodigital2024-06-11
dc.format.extent10 páginas
dc.fuente.origenORCID
dc.identifier.doi10.4067/S0034-98872019000800955
dc.identifier.issn0034-9887
dc.identifier.pubmedid31859959
dc.identifier.pubmedid31859959
dc.identifier.scieloidS0034-98872019000800955
dc.identifier.scopusidSCOPUS_ID:2-s2.0-85077072129
dc.identifier.urihttp://dx.doi.org/10.4067/S0034-98872019000800955
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86739
dc.identifier.wosidWOS:000493302200002
dc.information.autorucEscuela de Medicina; Guerra Castro, Juan Francisco; S/I; 159745
dc.information.autorucEscuela de Medicina; Quezada González, José Luis; 0000-0003-0722-099X; 127016
dc.information.autorucEscuela de Medicina; Benitez Gajardo, Carlos Esteban; 0000-0002-7010-9891; 9202
dc.information.autorucEscuela de Medicina; Pattillo Silva, Juan Carlos; S/I; 18294
dc.information.autorucEscuela de Medicina; Gana Ansaldo, Juan Cristobal; 0000-0002-0400-2164; 8726
dc.information.autorucEscuela de Medicina; Concha Pinto, Mario Rodrigo; S/I; 61460
dc.information.autorucEscuela de Medicina; Cortinez Fernandez, Luis Ignacio; 0000-0001-8544-8768; 79356
dc.information.autorucEscuela de Medicina; Vera Alarcón, María Magdalena; 0000-0002-2969-3408; 226652
dc.information.autorucEscuela de Medicina; Briceno Valenzuela, Eduardo Andres; S/I; 18751
dc.information.autorucEscuela de Medicina; Dib Marambio, Martin Javier; S/I; 1103640
dc.information.autorucEscuela de Medicina; Jarufe Cassis, Nicolas Patricio; S/I; 104492
dc.information.autorucEscuela de Medicina; Arrese Jimenez, Marco Antonio; 0000-0002-0499-4191; 76095
dc.issue.numero8
dc.language.isoes
dc.nota.accesocontenido completo
dc.pagina.final964
dc.pagina.inicio955
dc.revistaRevista Médica de Chile
dc.rightsacceso abierto
dc.rights.license CC BY 4.0 DEED Atribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.en
dc.subjectLearning Curve
dc.subjectSurvival Analysis
dc.subjectLiver Transplantation
dc.subject610
dc.titleTrasplante hepático: Evolución, curva de aprendizaje y resultados después de los primeros 300 casos
dc.title.alternativeLiver transplantation: Development, learning curve and results after the first 300 cases
dc.typeartículo
dc.volumen147
sipa.codpersvinculados159745
sipa.codpersvinculados127016
sipa.codpersvinculados9202
sipa.codpersvinculados18294
sipa.codpersvinculados8726
sipa.codpersvinculados61460
sipa.codpersvinculados79356
sipa.codpersvinculados226652
sipa.codpersvinculados18751
sipa.codpersvinculados1103640
sipa.codpersvinculados104492
sipa.codpersvinculados76095
sipa.trazabilidadConveris;20-07-2021
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