Powerful decomposition of complex traits in a diploid model

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dc.contributor.authorHallin, Johan
dc.contributor.authorMaertens, Kaspar
dc.contributor.authorYoung, Alexander I.
dc.contributor.authorZackrisson, Martin
dc.contributor.authorSalinas, Francisco
dc.contributor.authorParts, Leopold
dc.contributor.authorWarringer, Jonas
dc.contributor.authorLiti, Gianni
dc.date.accessioned2024-01-10T12:41:38Z
dc.date.available2024-01-10T12:41:38Z
dc.date.issued2016
dc.description.abstractExplaining trait differences between individuals is a core and challenging aim of life sciences. Here, we introduce a powerful framework for complete decomposition of trait variation into its underlying genetic causes in diploid model organisms. We sequence and systematically pair the recombinant gametes of two intercrossed natural genomes into an array of diploid hybrids with fully assembled and phased genomes, termed Phased Outbred Lines (POLs). We demonstrate the capacity of this approach by partitioning fitness traits of 6,642 Saccharomyces cerevisiae POLs across many environments, achieving near complete trait heritability and precisely estimating additive (73%), dominance (10%), second (7%) and third (1.7%) order epistasis components. We map quantitative trait loci (QTLs) and find nonadditive QTLs to outnumber (3:1) additive loci, dominant contributions to heterosis to outnumber overdominant, and extensive pleiotropy. The POL framework offers the most complete decomposition of diploid traits to date and can be adapted to most model organisms.
dc.description.funderLabex SIGNALIFE
dc.description.funderEuropean Regional Development Fund through the BioMedIT project
dc.description.funderCONICYT/FONDECYT
dc.description.funderMN-FISB
dc.description.funderSwedish Research Council
dc.description.funderResearch Council of Norway
dc.description.funderMarie Curie International Outgoing Fellowship
dc.description.funderWellcome Trust
dc.description.funderEstonian Research Council
dc.description.funderATIP-Avenir (CNRS/INSERM)
dc.description.funderARC
dc.description.funderFP7-PEOPLE-CIG
dc.description.funderANR
dc.description.funderCanceropole PACA
dc.description.funderDuPont Young Professor Award
dc.description.funderANR (Labex SIGNALIFE)
dc.description.funderBecas Chile
dc.fechaingreso.objetodigital2024-04-25
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1038/ncomms13311
dc.identifier.issn2041-1723
dc.identifier.pubmedidMEDLINE:27804950
dc.identifier.urihttps://doi.org/10.1038/ncomms13311
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77436
dc.identifier.wosidWOS:000386681200001
dc.information.autorucCiencias Biológicas;Salinas F;S/I;237942
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherNATURE PUBLISHING GROUP
dc.revistaNATURE COMMUNICATIONS
dc.rightsacceso abierto
dc.subjectSACCHAROMYCES-CEREVISIAE
dc.subjectMISSING HERITABILITY
dc.subjectGENETIC INTERACTIONS
dc.subjectQUANTITATIVE TRAITS
dc.subjectPOPULATION GENOMICS
dc.subjectVARIANCE-COMPONENTS
dc.subjectYEAST POPULATION
dc.subjectHETEROSIS
dc.subjectEVOLUTION
dc.subjectGROWTH
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePowerful decomposition of complex traits in a diploid model
dc.typeartículo
dc.volumen7
sipa.codpersvinculados237942
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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