Maternal H. pylori is associated with differential fecal microbiota in infants born by vaginal delivery

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dc.article.number7305
dc.catalogadorjca
dc.contributor.authorHernández, Caroll D.
dc.contributor.authorShin, Hakdong
dc.contributor.authorTroncoso, Paula A.
dc.contributor.authorVera, Macarena H.
dc.contributor.authorVillagran, Andrea A.
dc.contributor.authorRodríguez-Rivera, Selena M.
dc.contributor.authorOrtiz, Marlene A.
dc.contributor.authorSerrano, Carolina A.
dc.contributor.authorBorzutzky Schachter, Arturo
dc.contributor.authorDomínguez-Bello, María Gloria
dc.contributor.authorHarris, Paul R.
dc.date.accessioned2023-01-19T14:02:59Z
dc.date.available2023-01-19T14:02:59Z
dc.date.issued2020
dc.description.abstractHelicobacter pylori colonization may affect the mucosal immune system through modification of microbiota composition and their interactions with the host. We hypothesized that maternal H. pylori status affects the maternal intestinal microbiota of both mother and newborn. In this study, we determine the structure of the fecal microbiota in mothers and neonates according to maternal H. pylori status and delivery mode. We included 22 mothers and H. pylori infection was determined by fecal antigen test. Eleven mothers (50%) were H. pylori-positive (7 delivering vaginally and 4 by C-section), and 11 were negative (6 delivering vaginally and 5 by C-section). Stool samples were obtained from mothers and infants and the fecal DNA was sequenced. The fecal microbiota from mothers and their babies differed by the maternal H. pylori status, only in vaginal birth, not in C-section delivery. All 22 infants tested negative for fecal H. pylori at 15 days of age, but those born vaginally –and not those by C-section- showed differences in the infant microbiota by maternal H. pylori status (PERMANOVA, p = 0.01), with higher abundance of Enterobacteriaceae and Veillonella, in those born to H. pylori-positive mothers. In conclusion, the structure of the infant fecal microbiota is affected by the maternal H. pylori status only in infants born vaginally, suggesting that the effect could be mediated by labor and birth exposures.
dc.fechaingreso.objetodigital2023-01-19
dc.format.extent10 páginas
dc.fuente.origenSIPA
dc.identifier.converisid1
dc.identifier.doi10.1038/s41598-020-64296-7
dc.identifier.eissn2045-2322
dc.identifier.urihttps://doi.org/10.1038/s41598-020-64296-7
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/66375
dc.information.autorucFacultad de medicina ; Borzutzky Schachter, Arturo ; 0000-0002-7904-262X ; 5897
dc.language.isoen
dc.nota.accesoContenido completo
dc.revistaScientific Reports
dc.rightsacceso abierto
dc.titleMaternal H. pylori is associated with differential fecal microbiota in infants born by vaginal delivery
dc.typeartículo
dc.volumen10
sipa.codpersvinculados5897
sipa.indexWoS
sipa.indexPubmed
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