Citosine-Adenine-Repeat Microsatellite of 11 beta-hydroxysteroid dehydrogenase 2 Gene in Hypertensive Children

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dc.contributor.authorValdivia, Carolina
dc.contributor.authorCarvajal, Cristian A.
dc.contributor.authorCampino, Carmen
dc.contributor.authorAllende, Fidel
dc.contributor.authorMartinez Aguayo, Alejandro
dc.contributor.authorBaudrand, Rene
dc.contributor.authorVecchiola, Andrea
dc.contributor.authorLagos, Carlos F.
dc.contributor.authorTapia Castillo, Alejandra
dc.contributor.authorFuentes, Cristobal A.
dc.contributor.authorAglony, Marlene
dc.contributor.authorSolari, Sandra
dc.contributor.authorKalergis, Alexis M.
dc.contributor.authorGarcia, Hernan
dc.contributor.authorOwen, Gareth I.
dc.contributor.authorFardella, Carlos E.
dc.date.accessioned2024-01-10T12:38:02Z
dc.date.available2024-01-10T12:38:02Z
dc.date.issued2016
dc.description.abstractBACKGROUND
dc.description.abstractThe impairment of 11 beta-hydroxysteroid dehydrogenase type 2 enzyme (11 beta HSD2) results in an inefficient conversion of cortisol to cortisone, which triggers hypertension. Cytosine-adenine repeat (CA repeat) microsatellite has been associated with low HSD11B2 gene expression.
dc.description.abstractAIM
dc.description.abstractTo determine whether the CA-repeat length in intron 1 affect the serum cortisol to cortisone (F/E) ratio and/or blood pressure (BP) levels in pediatric subjects.
dc.description.abstractSUBJECTS AND METHODS
dc.description.abstractEighty-one hypertensive (HT) and 117 normotensive (NT) subjects participated in this study. We measured BP levels, as well as the F and E and F/E ratio in morning sera and 12-hour urine samples. The length of CA repeats was determined through fragment analysis. We compared the allele distribution between the HT and NT groups, and the patients were dichotomized into groups with short alleles (S) (<21 CA repeats) or long alleles (L), and also in groups according genotype (allele combination: S/S and S/L + L/L).
dc.description.abstractRESULTS
dc.description.abstractWe found no differences in the distribution of CA-repeat allelic length between the NT and HT groups (P = 0.7807), and there was no correlation between the CA-repeat allelic length and BP (P = 0.1151) levels or the serum F/E ratio (P = 0.6778). However, the serum F/E ratio was higher in the HT group than in the NT group (P = 0.0251). The serum F/E ratio was associated with systolic BP index independent of body mass index only in HT group.
dc.description.abstractCONCLUSIONS
dc.description.abstractThe CA-repeat length did not influence BP levels or serum F/E ratios in pediatric subjects. However, the serum F/E ratio was associated with BP, suggesting a role of 11 beta HSD2 in mineralocorticoid hypertension.
dc.description.funderChilean Grant FONDECYT
dc.description.funderChilean Grant FONDEF IDeA
dc.description.funderChilean Grant CORFO
dc.description.funderMillennium Institute of Immunology and Immunotherapy (MIII)
dc.fechaingreso.objetodigital2024-04-30
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1093/ajh/hpv052
dc.identifier.eissn1941-7225
dc.identifier.issn0895-7061
dc.identifier.pubmedidMEDLINE:25907225
dc.identifier.urihttps://doi.org/10.1093/ajh/hpv052
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76972
dc.identifier.wosidWOS:000369996400006
dc.information.autorucMedicina; Allende F;S/I;1004550
dc.information.autorucMedicina; Fardella C;S/I;66235
dc.information.autorucCiencias Biológicas; Fuentes C;S/I;1012852
dc.information.autorucCiencias Biológicas; Kalergis A;S/I;90610
dc.information.autorucMedicina; Lagos C;S/I;7337
dc.information.autorucMedicina; Owen G;S/I;1000459
dc.information.autorucMedicina; Solari S;S/I;1871
dc.information.autorucMedicina;Aglony M;S/I;1273
dc.information.autorucMedicina;Baudrand R;S/I;1024
dc.information.autorucMedicina;Carvajal C;S/I;8586
dc.information.autorucMedicina;Garcia H;S/I;1006495
dc.information.autorucMedicina;Martinez A;S/I;1003862
dc.information.autorucMedicina;Tapia A;S/I;1012854
dc.information.autorucMedicina;Valdivia C;S/I;1002689
dc.information.autorucMedicina;Vecchiola A;S/I;123319
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final32
dc.pagina.inicio25
dc.publisherOXFORD UNIV PRESS
dc.revistaAMERICAN JOURNAL OF HYPERTENSION
dc.rightsacceso restringido
dc.subject11 beta HSD2
dc.subjectarterial hypertension
dc.subjectblood pressure
dc.subjectHSD11B2
dc.subjecthypertension
dc.subjectmicrosatellite region
dc.subjectshort tandem repeat (STR)
dc.subjectCA repeat
dc.subjectPLASMA-RENIN ACTIVITY
dc.subjectURINARY FREE CORTISOL
dc.subjectHSD11B2 CA-REPEAT
dc.subjectMINERALOCORTICOID RECEPTORS
dc.subjectBLOOD-PRESSURE
dc.subjectTYPE-2
dc.subjectPOLYMORPHISMS
dc.subjectALDOSTERONE
dc.subjectEXPRESSION
dc.subjectPROMOTER
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCitosine-Adenine-Repeat Microsatellite of 11 beta-hydroxysteroid dehydrogenase 2 Gene in Hypertensive Children
dc.typeartículo
dc.volumen29
sipa.codpersvinculados1004550
sipa.codpersvinculados66235
sipa.codpersvinculados1012852
sipa.codpersvinculados90610
sipa.codpersvinculados7337
sipa.codpersvinculados1000459
sipa.codpersvinculados1871
sipa.codpersvinculados1273
sipa.codpersvinculados1024
sipa.codpersvinculados8586
sipa.codpersvinculados1006495
sipa.codpersvinculados1003862
sipa.codpersvinculados1012854
sipa.codpersvinculados1002689
sipa.codpersvinculados123319
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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