3D whole-heart isotropic sub-millimeter resolution coronary magnetic resonance angiography with non-rigid motion-compensated PROST.

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dc.contributor.authorBustin, Aurelien.
dc.contributor.authorBotnar, René Michael
dc.contributor.authorPrieto Vásquez, Claudia
dc.contributor.authorRashid, Imran.
dc.contributor.authorCruz, Gastao.
dc.contributor.authorHajhosseiny, R.
dc.contributor.authorCorreia, Teresa.
dc.contributor.authorNeji, Radhouene.
dc.contributor.authorRajani, Ronak.
dc.contributor.authorIsmail, Tevfik F.
dc.date.accessioned2020-04-21T17:37:37Z
dc.date.available2020-04-21T17:37:37Z
dc.date.issued2020
dc.date.updated2020-04-19T00:04:06Z
dc.description.abstractAbstract Background To enable free-breathing whole-heart sub-millimeter resolution coronary magnetic resonance angiography (CMRA) in a clinically feasible scan time by combining low-rank patch-based undersampled reconstruction (3D-PROST) with a highly accelerated non-rigid motion correction framework. Methods Non-rigid motion corrected CMRA combined with 2D image-based navigators has been previously proposed to enable 100% respiratory scan efficiency in modestly undersampled acquisitions. Achieving sub-millimeter isotropic resolution with such techniques still requires prohibitively long acquisition times. We propose to combine 3D-PROST reconstruction with a highly accelerated non-rigid motion correction framework to achieve sub-millimeter resolution CMRA in less than 10 min. Ten healthy subjects and eight patients with suspected coronary artery disease underwent 4–5-fold accelerated free-breathing whole-heart CMRA with 0.9 mm3 isotropic resolution. Vessel sharpness, vessel length and image quality obtained with the proposed non-rigid (NR) PROST approach were compared against translational correction only (TC-PROST) and a previously proposed NR motion-compensated technique (non-rigid SENSE) in healthy subjects. For the patient study, image quality scoring and visual comparison with coronary computed tomography angiography (CCTA) were performed. Results Average scan times [min:s] were 6:01 ± 0:59 (healthy subjects) and 8:29 ± 1:41 (patients). In healthy subjects, vessel sharpness of the left anterior descending (LAD) and right (RCA) coronary arteries were improved with the proposed non-rigid PROST (LAD: 51.2 ± 8.8%, RCA: 61.2 ± 9.1%) in comparison to TC-PROST (LAD: 43.8 ± 5.1%, P = 0.051, RCA: 54.3 ± 8.3%, P = 0.218) and non-rigid SENSE (LAD: 46.1 ± 5.8%, P = 0.223, RCA: 56.7 ± 9.6%, P = 0.50), although differences were not statistically significant. The average visual image quality score was significantly higher for NR-PROST (LAD: 3.2 ± 0.6, RCA: 3.3 ± 0.7) compared with TC-PROST (LAD: 2.1 ± 0.6, P = 0.018, RCA: 2.0 ± 0.7, P = 0.014) and non-rigid SENSE (LAD: 2.3 ± 0.5, P = 0.008, RCA: 2.5 ± 0.7, P = 0.016). In patients, the proposed approach showed good delineation of the coronaries, in agreement with CCTA, with image quality scores and vessel sharpness similar to that of healthy subjects. Conclusions We demonstrate the feasibility of combining high undersampling factors with non-rigid motion-compensated reconstruction to obtain high-quality sub-millimeter isotropic CMRA images in ~ 8 min. Validation in a larger cohort of patients with coronary artery disease is now warranted.
dc.identifier.citationJournal of Cardiovascular Magnetic Resonance. 2020 Apr 16;22(1):24
dc.identifier.doi10.1186/s12968-020-00611-5
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/28692
dc.identifier.urihttps://doi.org/10.1186/s12968-020-00611-5
dc.issue.numeroNo. 24
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final16
dc.pagina.inicio1
dc.revistaJournal of Cardiovascular Magnetic Resonancees_ES
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.subjectAccelerated imaginges_ES
dc.subjectCoronary MR angiographyes_ES
dc.subjectIsotropic sub-millimeter resolutiones_ES
dc.subjectPROST reconstruction nonrigid motion compensationes_ES
dc.subject.ddc616.07548
dc.subject.deweyMedicina y saludes_ES
dc.title3D whole-heart isotropic sub-millimeter resolution coronary magnetic resonance angiography with non-rigid motion-compensated PROST.es_ES
dc.typeartículo
dc.volumenVol. 22
sipa.codpersvinculados1015313
sipa.codpersvinculados14195
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