Relevance of adjusted cut-off values in commercial serological immunoassays for Helicobacter pylori infection in children

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dc.catalogadorpau
dc.contributor.authorHarris, Paul R.
dc.contributor.authorPerez-Perez, G.
dc.contributor.authorZylberberg, A.
dc.contributor.authorRollán, A.
dc.contributor.authorSerrano, C.
dc.contributor.authorRiera, F.
dc.contributor.authorEinisman, H.
dc.contributor.authorGarcía, D.
dc.contributor.authorViviani, P.
dc.date.accessioned2024-01-19T19:22:45Z
dc.date.available2024-01-19T19:22:45Z
dc.date.issued2005
dc.description.abstractWe assessed the sensitivity and specificity of H. pylori IgG and IgA with a commercial immunoassay performed in Chile and a second non-commercial immunoassay performed in a reference laboratory in the United States, in serum of 80 children and adults referred for gastrointestinal endoscopies in a developing country. Overall, 56% of the patients were infected with H. pylori based on rapid urease test and staining techniques on gastric biopsies. When Receiver Operator Curves (ROC) were developed, the sensitivity and specificity were similar for IgG and IgA. Both immunoassays exhibited better specificity, positive and negative predictive value (NPV) in children than in adults when cut-off values were corrected according to the local population than when they were assessed using the cut-off values pre-defined in other populations. These results underline the need to establish more precise cut-off values corrected in the local populations where assessments of antibodies as diagnostic markers of H. pylori infection are planning. © 2005 Springer Science+Business Media, Inc.
dc.fuente.origenORCID-ene24
dc.identifier.doi10.1007/s10620-005-3015-9
dc.identifier.issn0717-6228
dc.identifier.urihttps://doi.org/10.1007/s10620-005-3015-9
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-27144488666&partnerID=MN8TOARS
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80845
dc.information.autorucEscuela de Medicina; Harris Diez, Paul Richard; 0000-0001-6226-0957; 80706
dc.issue.numero11
dc.language.isoen
dc.nota.accesoContenido parcial
dc.revistaDigestive Diseases and Sciences
dc.rightsacceso restringido
dc.subjectH. pylories_ES
dc.subjectIgG and IgA antibodieses_ES
dc.subjectImmunoassayes_ES
dc.subjectInfantses_ES
dc.titleRelevance of adjusted cut-off values in commercial serological immunoassays for Helicobacter pylori infection in childrenes_ES
dc.typeartículo
dc.volumen50
sipa.codpersvinculados80706
sipa.trazabilidadORCID;2024-01-08
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