Análisis de los fenotipos y genotipos de resistencia a eritromicina y clindamicina en cepas de Streptococcus pyogenes aisladas en Chile en un período de 10 años

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dc.catalogadorjlo
dc.contributor.authorRodríguez, Carlos
dc.contributor.authorRojas, Pablo
dc.contributor.authorWozniak, Aniela
dc.contributor.authorKalergis, Alexis M.
dc.contributor.authorCerón, Inés
dc.contributor.authorRiedel, Ingrid
dc.contributor.authorRomán, Juan C.
dc.contributor.authorVillarroel, Luis A.
dc.contributor.authorBerríos, Ximena
dc.contributor.authorBavestrello, Luis
dc.contributor.authorGarcía, Patricia
dc.date.accessioned2024-01-29T17:48:29Z
dc.date.available2024-01-29T17:48:29Z
dc.date.issued2011
dc.description.abstractBackground: Macrolide and lincosamide resistance in Streptococcus pyogenes is due to the acquisition of mef, ermB and ermA genes, which confer different resistance phenotypes, namely M, MLSBconstitutive and MLSBinducible respectively. The last report of resistance in Chile was done in the period 1990-1998, in which resistance to macrolides was 5.4%, with M phenotype as the predominant one. Aim: To characterize the evolution of erythromycin and clindamycin resistance and their associated genes in S. pyogenes strains isolated from patients with invasive and noninvasive infections in the period 1996 to 2005. Material and Methods: Resistance to erythromycin and clindamycin was determined in 1,282 clinical isolates using the disk diffusion test. Resistant isolates were analyzed by polymerase chain reaction (PCR) for the presence of the above mentioned resistance genes. Results: Global resistance to erythromycin and clindamycin was 3.5 and 0.7% respectively. Eighty percent of the resistant strains possessed the M. phenotype. Conclusions: Resistance levels of S. pyogenes have decreased in Chile in the last years. Most resistant strains have M phenotype in contrast to many countries in which the MLSB constitutive phenotype is the predominant one.
dc.fechaingreso.objetodigital2024-05-27
dc.fuente.origenORCID-ene24
dc.identifier.doi10.4067/S0034-98872011000900005
dc.identifier.issn0717-6163
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-81355142613&partnerID=MN8TOARS
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81017
dc.information.autorucEscuela de Medicina; Kalergis Parra, Alexis Mikes; 0000-0001-7622-5263; 90610
dc.information.autorucEscuela de Medicina; Villarroel Del Pino, Luis Antonio; 0000-0001-9603-937X; 77182
dc.issue.numero9
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final1149
dc.pagina.inicio1143
dc.revistaRevista Medica de Chile
dc.rightsacceso abierto
dc.subjectBacterial
dc.subject Drug resistance
dc.subjectGenetic markers
dc.subjectStreptococcus pyogenes
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleAnálisis de los fenotipos y genotipos de resistencia a eritromicina y clindamicina en cepas de Streptococcus pyogenes aisladas en Chile en un período de 10 años
dc.title.alternativeResistance phenotypes and genotypes of streptococcus pyogenes clinical isolates in Chile over a 10-year period
dc.typeartículo
dc.volumen139
sipa.codpersvinculados90610
sipa.codpersvinculados77182
sipa.trazabilidadORCID;2024-01-15
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