Hepatitis C virus quasispecies in plasma and peripheral blood mononuclear cells of treatment naive chronically infected patients

Simple item page
dc.contributor.authorVera Otarola, J.
dc.contributor.authorBarria, M. I.
dc.contributor.authorLeon, U.
dc.contributor.authorMarsac, D.
dc.contributor.authorCarvallo, P.
dc.contributor.authorSoza, A.
dc.contributor.authorLopez Lastra, M.
dc.date.accessioned2024-01-10T13:13:27Z
dc.date.available2024-01-10T13:13:27Z
dc.date.issued2009
dc.description.abstractPeripheral blood mononuclear cells (PBMCs) from 45 treatment naive, HIV-negative, chronically hepatitis C virus (HCV)-infected patients were analyzed for the presence of HCV RNA. Viral RNA was detected in 73% of the studied patients. Single-strand conformation polymorphism assays and sequence analysis of the HCV 5'untranslated regions amplified from RNA recovered from both Plasma and PBMCs suggested virus compartmentalization in 57.6% of patients studied. In summary, our study presents evidence that HCV RNA can be found in PBMCs of treatment naive chronically infected patients that are not immunocompromised or co-infected with the human immunodeficiency virus.
dc.description.funderFONDECYT
dc.description.funderMECESUP-USACH
dc.description.funderCONICYT
dc.description.funderFONDECYT
dc.fechaingreso.objetodigital2024-05-07
dc.format.extent11 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1111/j.1365-2893.2009.01112.x
dc.identifier.eissn1365-2893
dc.identifier.issn1352-0504
dc.identifier.pubmedidMEDLINE:19254350
dc.identifier.urihttps://doi.org/10.1111/j.1365-2893.2009.01112.x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78306
dc.identifier.wosidWOS:000268987500004
dc.information.autorucCiencias Biológicas;Carvallo P;S/I;104361
dc.information.autorucMedicina;León U;S/I;1005748
dc.information.autorucMedicina;López-Lastra M;S/I;84823
dc.information.autorucMedicina;Marsac D;S/I;146335
dc.information.autorucMedicina;Soza A;S/I;461
dc.issue.numero9
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final643
dc.pagina.inicio633
dc.publisherWILEY
dc.revistaJOURNAL OF VIRAL HEPATITIS
dc.rightsacceso restringido
dc.subjectcompartmentalization
dc.subjectHCV
dc.subjectPBMC
dc.subjectNEGATIVE-STRAND RNA
dc.subjectIN-VITRO
dc.subjectEXTRAHEPATIC REPLICATION
dc.subjectHEMATOPOIETIC-CELLS
dc.subjectVIRAL SEQUENCES
dc.subjectHCV RNA
dc.subjectLIVER
dc.subjectPERSISTENCE
dc.subjectSERUM
dc.subjectVIVO
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHepatitis C virus quasispecies in plasma and peripheral blood mononuclear cells of treatment naive chronically infected patients
dc.typeartículo
dc.volumen16
sipa.codpersvinculados104361
sipa.codpersvinculados1005748
sipa.codpersvinculados84823
sipa.codpersvinculados146335
sipa.codpersvinculados461
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Hepatitis C virus quasispecies in plasma and peripheral blood mononuclear cells of treatment naive chronically infected patients.pdf
Size:
2.76 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas