Synthesis of 2-ethoxycarbonylthieno[2,3-<i>b</i>]quinolines in biomass-derived solvent γ-valerolactone and their biological evaluation against protein tyrosine phosphatase 1B

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dc.contributor.authorMu, Xu-Yang
dc.contributor.authorWang, Zhi-Jia
dc.contributor.authorFeng, Bo
dc.contributor.authorXu, Lei
dc.contributor.authorGao, Li-Xin
dc.contributor.authorSatheeshkumar, Rajendran
dc.contributor.authorLi, Jia
dc.contributor.authorZhou, Yu-Bo
dc.contributor.authorWang, Wen-Long
dc.date.accessioned2025-01-20T23:54:13Z
dc.date.available2025-01-20T23:54:13Z
dc.date.issued2021
dc.description.abstractA series of 2-ethoxycarbonylthieno[2,3-b]quinolines were synthesized in the bio-derived "green" solvent gamma-valerolactone (GVL) and evaluated for their inhibitory activities against PTP1B, the representative compound 6a displayed an IC50 value of 8.04 +/- 0.71 mu M with 4.34-fold preference over TCPTP. These results provided novel lead compounds for the design of inhibitors of PTP1B as well as other PTPs.
dc.fuente.origenWOS
dc.identifier.doi10.1039/d0ra09247a
dc.identifier.eissn2046-2069
dc.identifier.urihttps://doi.org/10.1039/d0ra09247a
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95022
dc.identifier.wosidWOS:000611287900003
dc.issue.numero6
dc.language.isoen
dc.pagina.final3220
dc.pagina.inicio3216
dc.revistaRsc advances
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSynthesis of 2-ethoxycarbonylthieno[2,3-<i>b</i>]quinolines in biomass-derived solvent γ-valerolactone and their biological evaluation against protein tyrosine phosphatase 1B
dc.typeartículo
dc.volumen11
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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