Clinical characteristics and outcomes of patients with 2009 influenza A(H1N1) virus infection with respiratory failure requiring mechanical ventilation

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dc.contributor.authorNin, Nicolas
dc.contributor.authorSoto, Luis
dc.contributor.authorHurtado, Javier
dc.contributor.authorLorente, Jose A.
dc.contributor.authorBuroni, Maria
dc.contributor.authorArancibia, Francisco
dc.contributor.authorUgarte, Sebastian
dc.contributor.authorBagnulo, Homero
dc.contributor.authorCardinal, Pablo
dc.contributor.authorBugedo, Guillermo
dc.contributor.authorEchevarria, Estrella
dc.contributor.authorDeicas, Alberto
dc.contributor.authorOrtega, Carlos
dc.contributor.authorFrutos Vivar, Fernando
dc.contributor.authorEsteban, Andres
dc.date.accessioned2024-01-10T12:04:39Z
dc.date.available2024-01-10T12:04:39Z
dc.date.issued2011
dc.description.abstractPurpose: The purpose of the study was to describe the clinical characteristics and outcomes of critically ill patients with 2009 influenza A(H1N1).
dc.description.abstractMethods: An observational study of patients with confirmed or probable 2009 influenza A(H1N1) and respiratory failure requiring mechanical ventilation was performed.
dc.description.abstractResults: We studied 96 patients (mean age, 45 [14] years [mean, SD]; 44% female). Shock and acute respiratory distress syndrome were diagnosed during the first 72 hours of admission in 43% and 72% of patients, respectively. Noninvasive positive pressure ventilation was used in 45% of the patients, but failed in 77% of them. Bacterial pneumonia was diagnosed in 33% of cases, 8% during the first week (due to community-acquired microorganisms) and 25% after the first week (due to gram-negative bacilli and resistant gram-positive cocci). Intensive care unit mortality was 50%. Nonsurvivors differed from survivors in the prevalence of cardiovascular, respiratory, and hematologic failure on admission and late pneumonia. Reported causes of death were refractory hypoxia, multiorgan failure, and shock (50%, 38%, and 12% of all causes of death, respectively).
dc.description.abstractConclusions: Patients with 2009 influenza A(H1N1) and respiratory failure requiring mechanical ventilation often present with clinical criteria of acute respiratory distress syndrome and shock. Bacterial pneumonia is a frequent complication. Mortality is high and is primarily due to refractory hypoxia. (C) 2011 Elsevier Inc. All rights reserved.
dc.fechaingreso.objetodigital27-03-2024
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jcrc.2010.05.031
dc.identifier.issn0883-9441
dc.identifier.pubmedidMEDLINE:20688465
dc.identifier.urihttps://doi.org/10.1016/j.jcrc.2010.05.031
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75852
dc.identifier.wosidWOS:000289887800015
dc.information.autorucMedicina;GUILLERMO BUGEDO;S/I;60490
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final192
dc.pagina.inicio186
dc.publisherW B SAUNDERS CO-ELSEVIER INC
dc.revistaJOURNAL OF CRITICAL CARE
dc.rightsacceso restringido
dc.subjectInfluenza
dc.subjectH1N1
dc.subjectMechanical ventilation
dc.subjectARDS
dc.subjectA H1N1 VIRUS
dc.subjectVACCINATION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleClinical characteristics and outcomes of patients with 2009 influenza A(H1N1) virus infection with respiratory failure requiring mechanical ventilation
dc.typeartículo
dc.volumen26
sipa.codpersvinculados60490
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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