Simultaneous [18F]fluoride and gadobutrol enhanced coronary positron emission tomography/magnetic resonance imaging for in vivo plaque characterization

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dc.catalogadorpva
dc.contributor.authorWurster, Thomas H.
dc.contributor.authorLandmesser, Ulf
dc.contributor.authorAbdelwahed, Youssef S.
dc.contributor.authorSkurk, Carsten
dc.contributor.authorMorguet, Andreas
dc.contributor.authorLeistner, David M.
dc.contributor.authorFroehlich, Georg
dc.contributor.authorHaghikia, Arash
dc.contributor.authorEngel, Leif Christopher
dc.contributor.authorBotnar, René Michael
dc.contributor.authorSchuster, Andreas
dc.contributor.authorNoutsias, Michel
dc.contributor.authorSchulze, Daniel
dc.contributor.authorHamm, Bernd
dc.contributor.authorFurth, Christian
dc.contributor.authorBrenner, Winfried
dc.contributor.authorBigalke, Boris
dc.contributor.authorMakowski, Marcus R.
dc.date.accessioned2024-01-24T16:31:33Z
dc.date.available2024-01-24T16:31:33Z
dc.date.issued2022
dc.description.abstractAims F-18-sodium fluoride ([18F]fluoride) and gadobutrol are promising probes for positron emission tomography (PET) and magnetic resonance imaging (MRI) characterizing coronary artery disease (CAD) activity. Unlike [18F]fluoride-PET/computed tomography (CT), the potential of PET/MR using [18F]fluoride and gadobutrol simultaneously, has so far not been evaluated. This study assessed feasibility and diagnostic potential of [18F]fluoride and gadobutrol enhanced dual-probe PET/MR in patients with CAD. Methods and results Twenty-one patients (age, 66.7 +/- 6.7 years) with CAD scheduled for invasive coronary angiography (XCA) underwent simultaneous [18F]fluoride (mean activity/effective dose: 157.2 +/- 29.7 MBq/3.77 +/- 0.72 mSv) and gadobutrol enhanced PET/MR on an integrated PET/MRI (3 T) scanner. Optical coherence tomography (OCT) was used as reference. Target-to-background ratio (TBR, [18F]fluoride-PET) and contrast-to-noise ratio (CNR) values (MRI, gadobutrol) were calculated for each coronary segment. Previously suggested PET/CT-TBR thresholds for adverse coronary events were evaluated. High-risk plaques, i.e. calcified and non-calcified thin-cap fibroatheromas (TCFAs) were predominantly located in segments with a TBR >1.28 (P = 0.012). Plaques containing a lipid core on OCT, were more frequently detected in segments with a TBR >1.25 (P < 0.001). TBR values significantly correlated with maximum calcification thickness (P = 0.009), while fibrous cap thickness was significantly less in segments with a TBR >1.28 (P = 0.044). Above a TBR threshold of >1.28, CNR values significantly correlated with the presence of calcified TCFAs (P = 0.032). Conclusion Simultaneous [18F]fluoride and gadobutrol dual-probe PET/MRI is feasible in clinical practice and may facilitate the identification of high-risk patients. The combination of coronary MR-derived CNR values post gadobutrol and [18F]fluoride based TBR values may improve identification of high-risk plaque features.
dc.fechaingreso.objetodigital2024-01-24
dc.fuente.origenWOS
dc.identifier.doi10.1093/ehjci/jeab276
dc.identifier.eissn2047-2412
dc.identifier.issn2047-2404
dc.identifier.urihttp://doi.org/10.1093/ehjci/jeab276
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80939
dc.identifier.wosidWOS:000852304600029
dc.information.autorucEscuela de Ingeniería; Botnar, René Michael; 0000-0002-9447-4367; 1015313
dc.issue.numero10
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final1398
dc.pagina.inicio1391
dc.publisherOxford University Press
dc.revistaEuropean Heart Journal - Cardiovascular Imaginges_ES
dc.rightsacceso restringido
dc.subjectAtherosclerosises_ES
dc.subjectGadobutrol enhanced [18F]fluoride-PET/MRes_ES
dc.subjectVulnerable plaqueses_ES
dc.subjectOCTes_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSimultaneous [18F]fluoride and gadobutrol enhanced coronary positron emission tomography/magnetic resonance imaging for in vivo plaque characterizationes_ES
dc.typeartículo
dc.volumen23
sipa.codpersvinculados1015313
sipa.trazabilidadWOS;2022-10-11
sipa.trazabilidadORCID;2024-01-15
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