The influence of platelet-derived products on angiogenesis and tissue repair: a concise update

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dc.contributor.authorMartinez, C. E.
dc.contributor.authorSmith, P. C.
dc.contributor.authorAlvarado, V. A. P.
dc.date.accessioned2019-10-16T20:16:12Z
dc.date.available2019-10-16T20:16:12Z
dc.date.issued2015
dc.description.abstractPlatelet degranulation allows the release of a large amount of soluble mediators, is an essential step for wound healing initiation, and stimulates clotting, and angiogenesis. The latter process is one of the most critical biological events observed during tissue repair, increasing the growth of blood vessels in the maturing wound. Angiogenesis requires the action of a variety of growth factors that act in an appropriate physiological ratio to assure functional blood vessel restoration. Platelets release main regulators of angiogenesis: Vascular Endothelial Growth Factors (VEGFs), basic fibroblast growth factor (FGF-2), and Platelet derived growth factors (PDGFs), among others. In order to stimulate tissue repair, platelet derived fractions have been used as an autologous source of growth factors and biomolecules, namely Platelet Rich Plasma (PRP), Platelet Poor Plasma (PPP), and Platelet Rich Fibrin (PRF). The continuous release of these growth factors has been proposed to promote angiogenesis both in vitro and in vivo. Considering the existence of clinical trials currently evaluating the efficacy of autologous PRP, the present review analyses fundamental questions regarding the putative role of platelet derived fractions as regulators of angiogenesis and evaluates the possible clinical implications of these formulations.
dc.format.extent1 página
dc.fuente.origenFacultad de Medicina
dc.identifier.doi10.3389/fphys.2015.00290
dc.identifier.issn1664-042X
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/26572
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.inicio7
dc.revistaFrontiers in Physiologyes_ES
dc.rightsacceso abierto
dc.subjectplatelet poor plasmaes_ES
dc.subjectplatelet rich plasmaes_ES
dc.subjectangiogenesises_ES
dc.subjecttissuees_ES
dc.subjectengineeringes_ES
dc.subjectgrowth factorses_ES
dc.subjectendothelial-cell proliferationes_ES
dc.subjectmesenchymal stromal cellses_ES
dc.subjectepidermal-growth-factores_ES
dc.subjectrich plasmaes_ES
dc.subjectregenerative medicinees_ES
dc.subjectbone-marrowes_ES
dc.subjectprogenitor cellses_ES
dc.subjectanimal serumes_ES
dc.subjectstem-cellses_ES
dc.subjectin-vitroes_ES
dc.subjectPhysiologyes_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleThe influence of platelet-derived products on angiogenesis and tissue repair: a concise updatees_ES
dc.typeartículo
dc.volumenVol. 6
sipa.codpersvinculados1008613
sipa.codpersvinculados1006488
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