Birth weight is inversely associated with blood pressure and serum aldosterone and cortisol levels in children

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dc.contributor.authorMartinez Aguayo, Alejandro
dc.contributor.authorAglony, Marlene
dc.contributor.authorBancalari, Rodrigo
dc.contributor.authorAvalos, Carolina
dc.contributor.authorBolte, Lillian
dc.contributor.authorGarcia, Hernan
dc.contributor.authorLoureiro, Carolina
dc.contributor.authorCarvajal, Cristian
dc.contributor.authorCampino, Carmen
dc.contributor.authorInostroza, Andrea
dc.contributor.authorFardella, Carlos
dc.date.accessioned2024-01-10T12:04:29Z
dc.date.available2024-01-10T12:04:29Z
dc.date.issued2012
dc.description.abstractContext Low birth weight has been independently associated with adult hypertension, and renin-angiotensin system (RAS) plays a role in this connection.
dc.description.abstractObjective To characterize the associations between birth weight (BW) and serum aldosterone (SA), serum cortisol, plasma renin activity (PRA) and blood pressure (BP). Design Cross-sectional study. Subjects Children from the community born at a gestational age >32 weeks.
dc.description.abstractMethods Systolic and diastolic BP indices (SBPi and DBPi) were calculated using the observed BP/50th percentile BP for gender, age and stature. BW was transformed to a standard deviation score (SDS) for gestational age, whereas SA, serum cortisol and PRA were transformed using the natural log.
dc.description.abstractResults We selected 288 subjects between the ages of 4 9 and 15 5 years (Females, 50%). After adjusting for body mass index (BMI) SDS and Tanner, multiple regression analysis revealed that BW (SDS) was both independently and inversely associated with the natural log of SA (beta = -0.065; P = 0.039), the natural log of serum cortisol (beta = -0.064; P = 0.009), SBPi (beta = 0.012; P = 0.020) and DBPi (beta = 0.023; P = 0 002). An association was not observed with PRA (P = 0.178) and aldosterone renin ratio (ARR) (P = 0.452). Serum cortisol levels were positively associated with SA (r = 0.125; P = 0.034), while an association with PRA (P = 0.251) and ARR (P = 0.052) was not observed.
dc.description.abstractConclusions The results of this study demonstrate an inverse association between birth weight and blood pressure and serum aldosterone and cortisol levels. This association is independent of BMI and Tanner, suggesting foetal programming of the hypothalamic-pituitary-adrenal axis.
dc.description.funderChilean Grant Fondecyt
dc.fechaingreso.objetodigital2024-05-07
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1111/j.1365-2265.2011.04308.x
dc.identifier.eissn1365-2265
dc.identifier.issn0300-0664
dc.identifier.pubmedidMEDLINE:22145676
dc.identifier.urihttps://doi.org/10.1111/j.1365-2265.2011.04308.x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75812
dc.identifier.wosidWOS:000302531200015
dc.information.autorucMedicina;Aglony M ;S/I;1273
dc.information.autorucMedicina;Avalos C ;S/I;1009844
dc.information.autorucMedicina;Bolte L ;S/I;18472
dc.information.autorucMedicina;Campino C;S/I;99519
dc.information.autorucMedicina;Carvajal C ;S/I;8586
dc.information.autorucMedicina;Fardella C ;S/I;66235
dc.information.autorucMedicina;Inostroza A;S/I;114125
dc.information.autorucMedicina;Loureiro C ;S/I;126948
dc.information.autorucMedicina;Martinez A ;S/I;1003862
dc.issue.numero5
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final718
dc.pagina.inicio713
dc.publisherWILEY
dc.revistaCLINICAL ENDOCRINOLOGY
dc.rightsacceso restringido
dc.subjectRENIN-ANGIOTENSIN SYSTEM
dc.subjectCHILDHOOD GROWTH
dc.subjectADULT HYPERTENSION
dc.subjectGESTATIONAL-AGE
dc.subjectMID-ADULTHOOD
dc.subjectRISK
dc.subjectFETAL
dc.subjectSIZE
dc.subjectDEHYDROGENASE
dc.subjectSENSITIVITY
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleBirth weight is inversely associated with blood pressure and serum aldosterone and cortisol levels in children
dc.typeartículo
dc.volumen76
sipa.codpersvinculados1273
sipa.codpersvinculados1009844
sipa.codpersvinculados18472
sipa.codpersvinculados99519
sipa.codpersvinculados8586
sipa.codpersvinculados66235
sipa.codpersvinculados114125
sipa.codpersvinculados126948
sipa.codpersvinculados1003862
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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