ACE2 and ANG-(1-7) in the rat uterus during early and late gestation

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dc.contributor.authorNeves, Liomar A. A.
dc.contributor.authorStovall, Kathryn
dc.contributor.authorJoyner, JaNae
dc.contributor.authorValdes, Gloria
dc.contributor.authorGallagher, Patricia E.
dc.contributor.authorFerrario, Carlos M.
dc.contributor.authorMerrill, David C.
dc.contributor.authorBrosnihan, K. Bridget
dc.date.accessioned2024-01-10T12:04:05Z
dc.date.available2024-01-10T12:04:05Z
dc.date.issued2008
dc.description.abstractThe present study was designed to determine ANG peptide content [ANG I, ANG II, ANG( 1-7)], ACE2 mRNA, and the immunocytochemical distribution of ANG-(1-7) and ACE2 in the uteroembryonic unit during early and late gestation in Sprague-Dawley rats and in a rat model of pregnancy-induced hypertension, the reduced uterine perfusion pressure (RUPP) model. At early pregnancy ANG-(1-7) and ACE2 staining were localized in the primary and secondary decidual zone and luminal and glandular epithelial cells. During late gestation, ANG-(1-7) and ACE2 staining was visualized in the labyrinth placenta and amniotic and yolk sac epithelium. Uterine ANG II concentration at early pregnancy was significantly decreased by 21-55% in the implantation and interimplantation sites compared with virgin rats, whereas ANG-(1-7) levels were maintained at prepregnancy levels. At late gestation, uterine concentrations of ANG I and ANG II were significantly increased (30% and 25%, respectively). In RUPP animals, ANG-(1-7) concentration is significantly reduced in the uterus (181 +/- 16 vs. 372 +/- 74 fmol/g of tissue) and placenta (143 +/- 26 vs. 197 +/- 20 fmol/g of tissue). ACE2 mRNA increased in the uterus of early pregnant compared with virgin rats, yet within the implantation site it was downregulated. At late pregnancy, ACE2 mRNA is elevated by 58% in the uterus and decreased by 59% in RUPP animals. The regulation of ANG-(1-7) and ACE2 in early and late pregnancy supports the hypothesis that ANG-(1-7) and ACE2 may act as a local autocrine/paracrine regulator throughout pregnancy, participating in the early (angiogenesis, apoptosis, and growth) and late (uteroplacental blood flow) events of pregnancy.
dc.description.funderNHLBI NIH HHS
dc.description.funderNICHD NIH HHS
dc.description.funderNATIONAL HEART, LUNG, AND BLOOD INSTITUTE
dc.fechaingreso.objetodigital2024-05-14
dc.format.extent11 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1152/ajpregu.00514.2007
dc.identifier.eissn1522-1490
dc.identifier.issn0363-6119
dc.identifier.pubmedidMEDLINE:17977916
dc.identifier.urihttps://doi.org/10.1152/ajpregu.00514.2007
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75681
dc.identifier.wosidWOS:000252243800019
dc.information.autorucMedicina;Valdés G;S/I;98654
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.publisherAMER PHYSIOLOGICAL SOC
dc.revistaAMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
dc.rightsacceso restringido
dc.subjectrenin-angiotensin system
dc.subjectimplantation
dc.subjectANGIOTENSIN-CONVERTING ENZYME
dc.subjectALDOSTERONE SYSTEM
dc.subjectRENIN
dc.subjectEXPRESSION
dc.subjectPREGNANCY
dc.subjectBRADYKININ
dc.subjectCYCLE
dc.subjectANGIOTENSIN-CONVERTING-ENZYME-2
dc.subjectPROGESTERONE
dc.subjectESTROGEN
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleACE2 and ANG-(1-7) in the rat uterus during early and late gestation
dc.typeartículo
dc.volumen294
sipa.codpersvinculados98654
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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