Contribution of Two-Dose Vaccination Toward the Reduction of COVID-19 Cases, ICU Hospitalizations and Deaths in Chile Assessed Through Explanatory Generalized Additive Models for Location, Scale, and Shape

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dc.article.number815036
dc.catalogadorjca
dc.contributor.authorReyes, Humberto
dc.contributor.authorDiethelm-Varela, Benjamin
dc.contributor.authorMendez Vejar, Constanza
dc.contributor.authorRebolledo-Zelada, Diego
dc.contributor.authorLillo-Dapremont, Bastián
dc.contributor.authorMuñoz, Sergio R.
dc.contributor.authorBueno, Susan M.
dc.contributor.authorGonzález, Pablo A.
dc.contributor.authorKalergis, Alexis
dc.date.accessioned2024-02-27T16:02:46Z
dc.date.available2024-02-27T16:02:46Z
dc.date.issued2022
dc.description.abstractObjectives: To assess the impact of the initial two-dose-schedule mass vaccination campaign in Chile toward reducing adverse epidemiological outcomes due to SARS-CoV-2 infection. Methods: Publicly available epidemiological data ranging from 3 February 2021 to 30 September 2021 were used to construct GAMLSS models that explain the beneficial effect of up to two doses of vaccination on the following COVID-19-related outcomes: new cases per day, daily active cases, daily occupied ICU beds and daily deaths. Results: Administered first and second vaccine doses, and the statistical interaction between the two, are strong, statistically significant predictors for COVID-19-related new cases per day (R2 = 0.847), daily active cases (R2 = 0.903), ICU hospitalizations (R2 = 0.767), and deaths (R2 = 0.827). Conclusion: Our models stress the importance of completing vaccination schedules to reduce the adverse outcomes during the pandemic. Future work will continue to assess the influence of vaccines, including booster doses, as the pandemic progresses, and new variants emerge. Policy Implications: This work highlights the importance of attaining full (two-dose) vaccination status and reinforces the notion that a second dose provides increased non-additive protection. The trends we observed may also support the inclusion of booster doses in vaccination plans. These insights could contribute to guiding other countries in their vaccination campaigns.
dc.fechaingreso.objetodigital2024-04-11
dc.fuente.origenORCID
dc.identifier.doi10.3389/fpubh.2022.815036
dc.identifier.issn2296-2565
dc.identifier.urihttps://doi.org/10.3389/fpubh.2022.815036
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81332
dc.information.autorucFacultad de Ciencias Biológicas;Reyes, Humberto;S/I;1047126
dc.information.autorucFacultad de Ciencias Biológicas;Diethelm Varela, Benjamín;0000-0002-5465-6924;217234
dc.information.autorucDepartamento de Ciencias de la Salud; Mendez Vejar, Constanza Soledad; 0000-0002-1509-4471; 1036010
dc.information.autorucFacultad de Ciencias Biológicas;Rebolledo Zelada, Diego;S/I;222100
dc.information.autorucFacultad de Ciencias Biológicas;Bueno, Susan;0000-0002-7551-8088;113541
dc.information.autorucFacultad de Ciencias Biológicas;Kalergis, Alexis;0000-0001-7622-5263;90610
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final10
dc.pagina.inicio1
dc.revistaFrontiers in Public Health
dc.rightsacceso abierto
dc.subjectGAMLSS models
dc.subjectCOVID-19
dc.subjectVaccination
dc.subjectICU hospitalizations
dc.subjectExplanatory models
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleContribution of Two-Dose Vaccination Toward the Reduction of COVID-19 Cases, ICU Hospitalizations and Deaths in Chile Assessed Through Explanatory Generalized Additive Models for Location, Scale, and Shape
dc.typeartículo
dc.volumen10
sipa.codpersvinculados1047126
sipa.codpersvinculados217234
sipa.codpersvinculados1036010
sipa.codpersvinculados222100
sipa.codpersvinculados113541
sipa.codpersvinculados90610
sipa.trazabilidadORCID;2024-01-15
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