Glutamatergic Receptor Trafficking and Delivery: Role of the Exocyst Complex

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dc.catalogadorjwg
dc.contributor.authorLira, Matías
dc.contributor.authorMira, Rodrigo G.
dc.contributor.authorCerpa Nebott Waldo Francisco
dc.contributor.authorCarvajal, Francisco J.
dc.contributor.authorInestrosa, Nibaldo C.
dc.contributor.authorZamorano, Pedro
dc.date.accessioned2024-01-26T13:19:39Z
dc.date.available2024-01-26T13:19:39Z
dc.date.issued2020
dc.description.abstractCells comprise several intracellular membrane compartments that allow them to function properly. One of these functions is cargo movement, typically proteins and membranes within cells. These cargoes ride microtubules through vesicles from Golgi and recycling endosomes to the plasma membrane in order to be delivered and exocytosed. In neurons, synaptic functions employ this cargo trafficking to maintain inter-neuronal communication optimally. One of the complexes that oversee vesicle trafficking and tethering is the exocyst. The exocyst is a protein complex containing eight subunits first identified in yeast and then characterized in multicellular organisms. This complex is related to several cellular processes, including cellular growth, division, migration, and morphogenesis, among others. It has been associated with glutamatergic receptor trafficking and tethering into the synapse, providing the molecular machinery to deliver receptor-containing vesicles into the plasma membrane in a constitutive manner. In this review, we discuss the evidence so far published regarding receptor trafficking and the exocyst complex in both basal and stimulated levels, comparing constitutive trafficking and long-term potentiation-related trafficking.
dc.fechaingreso.objetodigital2024-04-26
dc.fuente.origenScopus
dc.identifier.doi10.3390/cells9112402
dc.identifier.eissn20734409
dc.identifier.issn20734409
dc.identifier.pubmedid33153008
dc.identifier.scopusidSCOPUS_ID:85095794436
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80973
dc.identifier.wosidWOS:000592995500001
dc.information.autorucFacultad de Ciencias Biológicas; Cerpa Nebott Waldo Francisco; 0000-0001-7344-0144; 16584
dc.language.isoen
dc.nota.accesoContenido completo
dc.publisherNLM (Medline)
dc.revistaCells
dc.rightsacceso abierto
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleGlutamatergic Receptor Trafficking and Delivery: Role of the Exocyst Complex
dc.typeartículo
dc.volumen9
sipa.codpersvinculados16584
sipa.trazabilidadORCID;2024-01-15
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