DNA methylation in genes of longevity-regulating pathways: association with obesity and metabolic complications

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dc.catalogadordfo
dc.contributor.authorSalas Pérez, Francisca
dc.contributor.authorRamos López, Omar
dc.contributor.authorMansego, María L.
dc.contributor.authorMilagro, Fermín I.
dc.contributor.authorSantos, José L.
dc.contributor.authorRiezu-Boj, José I.
dc.contributor.authorAlfredo Martínez, J.
dc.date.accessioned2024-01-22T16:22:21Z
dc.date.available2024-01-22T16:22:21Z
dc.date.issued2019
dc.description.abstractAging is the main risk factor for most chronic diseases. Epigenetic mechanisms, such as DNA methylation (DNAm) plays a pivotal role in the regulation of physiological responses that can vary along lifespan. The aim of this research was to analyze the association between leukocyte DNAm in genes involved in longevity and the occurrence of obesity and related metabolic alterations in an adult population. Subjects from the MENA cohort (n=474) were categorized according to age (<45 vs 45>) and the presence of metabolic alterations: increased waist circumference, hypercholesterolemia, insulin resistance, and metabolic syndrome. The methylation levels of 58 CpG sites located at genes involved in longevity-regulating pathways were strongly correlated (FDR-adjusted< 0.0001) with BMI. Fifteen of them were differentially methylated (p<0.05) between younger and older subjects that exhibited at least one metabolic alteration. Six of these CpG sites, located at MTOR (cg08862778), ULK1 (cg07199894), ADCY6 (cg11658986), IGF1R (cg01284192), CREB5 (cg11301281), and RELA (cg08128650), were common to the metabolic traits, and CREB5, RELA, and ULK1 were statistically associated with age. In summary, leukocyte DNAm levels of several CpG sites located at genes involved in longevity-regulating pathways were associated with obesity and metabolic syndrome traits, suggesting a role of DNAm in aging-related metabolic alterations.
dc.fechaingreso.objetodigital2024-06-06
dc.fuente.origenORCID-ene24
dc.identifier.doi10.18632/aging.101882
dc.identifier.urihttps://doi.org/10.18632/aging.101882
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80895
dc.language.isoen
dc.nota.accesoContenido completo
dc.revistaAging
dc.rightsacceso abierto
dc.subjectEpigenetics
dc.subjectAging
dc.subjectMetabolic Syndrome
dc.subjectObesity
dc.subjectInsulin resistance
dc.subject.ddc600
dc.subject.deweyTecnologíaes_ES
dc.titleDNA methylation in genes of longevity-regulating pathways: association with obesity and metabolic complications
dc.typeartículo
sipa.trazabilidadWOS;05-06-2021
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