Interleukin-10 Production by T and B Cells Is a Key Factor to Promote Systemic Salmomnella enterica Serovar Typhimurium Infection in Mice

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dc.article.number889
dc.catalogadorgjm
dc.contributor.authorSalazar Tapia, Geraldyne Alessandra
dc.contributor.authorPeñaloza Cerda, Hernán F.
dc.contributor.authorPardo Roa, Catalina
dc.contributor.authorSchultz Lombardic, Bárbara M.
dc.contributor.authorMuñoz Durango, Natalia
dc.contributor.authorGómez Johnson, Roberto Sebastián
dc.contributor.authorSalazar Echegarai, Francisco Javier
dc.contributor.authorPizarro Solar, Daniela Paz
dc.contributor.authorRiedel, Claudia A.
dc.contributor.authorGonzález Muñoz, Pablo Alberto
dc.contributor.authorÁlvarez Lobos, Manuel
dc.contributor.authorKalergis Parra, Alexis Mikes
dc.contributor.authorBueno Ramírez, Susan
dc.date.accessioned2024-06-04T20:35:38Z
dc.date.available2024-06-04T20:35:38Z
dc.date.issued2017
dc.description.abstractSalmonella enterica serovar Typhimurium (S. Typhimurium) is a Gram-negative bacterium that produces disease in numerous hosts. In mice, oral inoculation is followed by intestinal colonization and subsequent systemic dissemination, which leads to severe pathogenesis without the activation of an efficient anti-Salmonella immune response. This feature suggests that the infection caused by S. Typhimurium may promote the production of anti-inflammatory molecules by the host that prevent efficient T cell activation and bacterial clearance. In this study, we describe the contribution of immune cells producing the anti-inflammatory cytokine interleukin-10 (IL-10) to the systemic infection caused by S. Typhimurium in mice. We observed that the production of IL-10 was required by S. Typhimurium to cause a systemic disease, since mice lacking IL-10 (IL-10(-/-)) were significantly more resistant to die after an infection as compared to wild-type (WT) mice. IL-10(-/-) mice had reduced bacterial loads in internal organs and increased levels of pro-inflammatory cytokines in serum at 5 days of infection. Importantly, WT mice showed high bacterial loads in tissues and no increase of cytokines in serum after 5 days of S. Typhimurium infection, except for IL-10. In WT mice, we observed a peak of il-10 messenger RNA production in ileum, spleen, and liver after 5 days of infection. Importantly, the adoptive transfer of T or B cells from WT mice restored the susceptibility of IL-10(-/-) mice to systemic S. Typhimurium infection, suggesting that the generation of regulatory cells in vivo is required to sustain a systemic infection by S. Typhimurium. These findings support the notion that IL-10 production from lymphoid cells is a key process in the infective cycle of S. Typhimurium in mice due to generation of a tolerogenic immune response that prevents bacterial clearance and supports systemic dissemination.
dc.fechaingreso.objetodigital2024-06-04
dc.fuente.origenRepositorio UC
dc.identifier.doi10.3389/fimmu.2017.00889
dc.identifier.issn1664-3224
dc.identifier.pubmedidMEDLINE:28824622
dc.identifier.urihttps://doi.org/10.3389/fimmu.2017.00889
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86411
dc.identifier.wosidWOS:000406885300001
dc.information.autorucFacultad de Ciencias Biológicas; Salazar Tapia, Geraldyne Alessandra; S/I; 1044678
dc.information.autorucFacultad de Ciencias Biológicas; Peñaloza Cerda, Hernán F.; S/I; 186994
dc.information.autorucFacultad de Ciencias Biológicas; Pardo Roa, Catalina; 0000-0002-5409-225X; 225251
dc.information.autorucFacultad de Ciencias Biológicas; Schultz Lombardic, Bárbara M.; 0000-0002-6201-6978; 186964
dc.information.autorucFacultad de Ciencias Biológicas; Muñoz Durango, Natalia; S/I; 218064
dc.information.autorucFacultad de Ciencias Biológicas; Gómez Johnson, Roberto Sebastián; S/I; 149736
dc.information.autorucFacultad de Ciencias Biológicas; Salazar Echegarai, Francisco Javier; S/I; 1011015
dc.information.autorucFacultad de Ciencias Biológicas; Pizarro Solar, Daniela Paz; S/I; 171975
dc.information.autorucFacultad de Ciencias Biológicas; González Muñoz, Pablo Alberto; 0000-0001-7709-6870; 15616
dc.information.autorucEscuela de Medicina; Álvarez Lobos, Manuel; S/I; 6131
dc.information.autorucFacultad de Ciencias Biológicas; Kalergis Parra, Alexis Mikes; 0000-0001-7622-5263; 90610
dc.information.autorucFacultad de Ciencias Biológicas; Bueno Ramírez, Susan; 0000-0002-7551-8088; 113541
dc.issue.numero889
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final12
dc.pagina.inicio1
dc.revistaFrontiers in Immunology
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 ATTRIBUTION 4.0 INTERNATIONAL Deed
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleInterleukin-10 Production by T and B Cells Is a Key Factor to Promote Systemic Salmomnella enterica Serovar Typhimurium Infection in Mice
dc.typeartículo
dc.volumen8
sipa.codpersvinculados1027885
sipa.codpersvinculados1044678
sipa.codpersvinculados186994
sipa.codpersvinculados225251
sipa.codpersvinculados186964
sipa.codpersvinculados218064
sipa.codpersvinculados149736
sipa.codpersvinculados1011015
sipa.codpersvinculados171975
sipa.codpersvinculados15616
sipa.codpersvinculados6131
sipa.codpersvinculados90610
sipa.codpersvinculados113541
sipa.trazabilidadConveris;02-07-2020
sipa.trazabilidadRepositorio UC;08-07-2021
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