Successful treatment of hyperthyroidism with amiodarone in a patient with propylthiouracil-induced acute hepatic failure

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dc.contributor.authorBrusco, F
dc.contributor.authorGonzalez, G
dc.contributor.authorSoto, N
dc.contributor.authorArteaga, E
dc.date.accessioned2024-01-10T13:43:41Z
dc.date.available2024-01-10T13:43:41Z
dc.date.issued2004
dc.description.abstractAcute hepatic failure is a rare and potentially lethal complication of propylthiouracil (PTU) use for hyperthyroidism. We present a 20-year-old woman with Basedow-Graves' disease who developed PTU-induced fulminant hepatitis, which progressed to acute hepatic failure with grade III hepatic encephalopathy. Laboratory evaluation ruled out the most common causes of fulminant hepatitis. We treated her hyperthyroidism with amiodarone (average daily dose, 200 mg) for 3 weeks, achieving rapid and persistent euthyroidism, (triiodothyronine [T-3] levels ranged between 64 and 109 ng/dL) without side effects. Amiodarone treatment did not abolish the thyroid radioactive iodine uptake (RAIU), allowing for subsequent treatment with radioactive iodine. The clinical course was favorable and the patient achieved full hepatic recovery 3 months after the hepatic failure was detected. After an extensive review of the literature, we believe that this is the first communication of the successful use of amiodarone to control hyperthyroidism in a patient with PTU-induced fulminant hepatitis.
dc.fechaingreso.objetodigital2024-04-26
dc.format.extent4 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1089/1050725042451202
dc.identifier.eissn1557-9077
dc.identifier.issn1050-7256
dc.identifier.pubmedidMEDLINE:15588385
dc.identifier.urihttps://doi.org/10.1089/1050725042451202
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78722
dc.identifier.wosidWOS:000225071800013
dc.information.autorucMedicina;Arteaga E;S/I;98586
dc.information.autorucMedicina;González G;S/I;100244
dc.issue.numero10
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final865
dc.pagina.inicio862
dc.publisherMARY ANN LIEBERT, INC
dc.revistaTHYROID
dc.rightsacceso restringido
dc.subjectGRAVES-DISEASE
dc.subjectTHYROID-HORMONES
dc.subjectSODIUM IPODATE
dc.subjectLIVER
dc.subjectHYPOTHYROIDISM
dc.subjectTHYROXINE
dc.subjectTRIIODOTHYRONINE
dc.subjectHEPATOTOXICITY
dc.subjectDEXAMETHASONE
dc.subjectDAMAGE
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleSuccessful treatment of hyperthyroidism with amiodarone in a patient with propylthiouracil-induced acute hepatic failure
dc.typeartículo
dc.volumen14
sipa.codpersvinculados98586
sipa.codpersvinculados100244
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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