Alterations in skeletal muscle morphology and mechanics in juvenile male Sprague Dawley rats exposed to a high-fat high-sucrose diet.

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dc.article.number12013
dc.catalogadordfo
dc.contributor.authorDelgado Bravo, Mauricio Antonio
dc.contributor.authorHart, David A.
dc.contributor.authorReimer, Raylene A.
dc.contributor.authorHerzog, Walter
dc.date.accessioned2023-08-23T15:11:25Z
dc.date.available2023-08-23T15:11:25Z
dc.date.issued2023
dc.description.abstractAlthough once a health concern largely considered in adults, the obesity epidemic is now prevalentin pediatric populations. While detrimental effects on skeletal muscle function have been seen inadulthood, the effects of obesity on skeletal muscle function in childhood is not clearly understood.The purpose of this study was to determine if the consumption of a high-fat high-sucrose (HFS) diet,starting in the post-weaning period, leads to changes in skeletal muscle morphology and mechanicsafter 14 weeks on the HFS diet. Eighteen 3-week-old male CD-Sprague Dawley rats were randomlyassigned to a HFS (C-HFS, n = 10) or standard chow diet (C-CHOW, n = 8). Outcome measures included: weekly energy intake, activity levels, oxygen consumption, body mass, body composition, metabolic profile, serum protein levels, and medial gastrocnemius gene expression, morphology, and mechanics. The main findings from this study were that C-HFS rats: (1) had a greater body mass and percent body fat than control rats; (2) showed early signs of metabolic syndrome; (3) demonstrated potential impairment in muscle remodeling; (4) produced lower relative muscle force; and (5) had a shift in the force–length relationship, indicating that the medial gastrocnemius had shorter muscle fiber lengths compared to those of C-CHOW rats. Based on the results of this study, we conclude that exposure to a HFS diet led to increased body mass, body fat percentage, and early signs of metabolic syndrome, resulting in functional deficits in MG of childhood rats.
dc.fechaingreso.objetodigital2023-08-22
dc.fuente.origenORCID
dc.identifier.doi10.1038/s41598-023-38487-x
dc.identifier.eissn2045-2322
dc.identifier.urihttp://europepmc.org/abstract/med/37491416
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74463
dc.information.autorucDepartamento de Ciencias de la Salud ; Delgado Bravo Mauricio Antonio ; 1013611 ; 0000-0001-7858-2264
dc.issue.numero13
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final14
dc.pagina.inicio1
dc.revistaScientific Reports
dc.rightsacceso abierto
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAlterations in skeletal muscle morphology and mechanics in juvenile male Sprague Dawley rats exposed to a high-fat high-sucrose diet.
dc.typeartículo
sipa.codpersvinculados1013611
sipa.trazabilidadORCID;2023-08-21
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