Emergence of three dimensional printed cardiac tissue: opportunities and challenges in cardiovascular diseases

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dc.catalogadorpva
dc.contributor.authorCharbe, Nitin B.
dc.contributor.authorZacconi, Flavia C. M.
dc.contributor.authorAmnerkar, Nikhil
dc.contributor.authorPardhi, Dinesh
dc.contributor.authorShukla, Priyank
dc.contributor.authorMukattash, Tareq L.
dc.contributor.authorMcCarron, Paul A.
dc.contributor.authorTambuwala, Murtaza M.
dc.date.accessioned2023-08-24T17:58:18Z
dc.date.available2023-08-24T17:58:18Z
dc.date.issued2019
dc.description.abstractThree-dimensional (3D) printing, also known as additive manufacturing, was developed originally for engineering applications. Since its early advancements, there has been a relentless development in enthusiasm for this innovation in biomedical research. It allows for the fabrication of structures with both complex geometries and heterogeneous material properties. Tissue engineering using 3D bio-printers can overcome the limitations of traditional tissue engineering methods. It can match the complexity and cellular microenvironment of human organs and tissues, which drives much of the interest in this technique. However, most of the preliminary evaluations of 3Dprinted tissues and organ engineering, including cardiac tissue, relies extensively on the lessons learned from traditional tissue engineering. In many early examples, the final printed structures were found to be no better than tissues developed using traditional tissue engineering methods. This highlights the fact that 3D bio-printing of human tissue is still very much in its infancy and more work needs to be done to realise its full potential. This can be achieved through interdisciplinary collaboration between engineers, biomaterial scientists and molecular cell biologists. This review highlights current advancements and future prospects for 3D bio-printing in engineering ex vivo cardiac tissue and associated vasculature, such as coronary arteries. In this context, the role of biomaterials for hydrogel matrices and choice of cells are discussed. 3D bio-printing has the potential to advance current research significantly and support the development of novel therapeutics which can improve the therapeutic outcomes of patients suffering fatal cardiovascular pathologies.
dc.description.funderVRAID (ex DIPUC)
dc.fechaingreso.objetodigital2023-08-24
dc.fuente.origenHistorial Académico
dc.identifier.citationZacconi Flavia Cristina Milag. Emergence of Three Dimensional Printed Cardiac Tissue : Opportunities and Challenges in Cardiovascular Diseases. 2019;15(3):188-204.
dc.identifier.doi10.2174/1573403X15666190112154710
dc.identifier.issn1573-403X
dc.identifier.urihttps://doi.org/10.2174/1573403X15666190112154710
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74485
dc.identifier.wosidWOS:000466991100005
dc.information.autorucEscuela de Química; Zacconi, Flavia C. M.; 0000-0002-3676-0453; 1011127
dc.issue.numero3
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final204
dc.pagina.inicio188
dc.revistaCurrent Cardiology Reviewses_ES
dc.rightsacceso restringido
dc.subjectCardiac tissue engineeringes_ES
dc.subjectVasculature networkes_ES
dc.subject3D bio-printinges_ES
dc.subjectBiomaterialses_ES
dc.subjectMicro-environmentes_ES
dc.subjectCardiovascular diseaseses_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods09 Industry, Innovation and Infrastructure
dc.subject.odspa09 Industria, innovación e infraestructura
dc.titleEmergence of three dimensional printed cardiac tissue: opportunities and challenges in cardiovascular diseaseses_ES
dc.typeartículo
dc.volumen15
sipa.codpersvinculados1011127
sipa.indexWoS
sipa.trazabilidadHistorial Académico;09-07-2021
sipa.trazabilidadORCID;2023-08-21
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