Association between indicators of systemic inflammation biomarkers during puberty with breast density and onset of menarche

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dc.contributor.authorMichels, Karin B.
dc.contributor.authorSantos Martín, José Luis
dc.contributor.authorKeller, Kristen
dc.contributor.authorPereira, Ana
dc.contributor.authorKim, Claire E.
dc.contributor.authorShepherd, John A.
dc.contributor.authorCorvalán, Camila
dc.contributor.authorBinder, Alexandra M.
dc.date.accessioned2020-10-08T12:32:40Z
dc.date.available2020-10-08T12:32:40Z
dc.date.issued2020
dc.date.updated2020-10-04T00:03:20Z
dc.description.abstractAbstract Background Systemic inflammation may play a role in shaping breast composition, one of the strongest risk factors for breast cancer. Pubertal development presents a critical window of breast tissue susceptibility to exogenous and endogenous factors, including pro-inflammatory markers. However, little is known about the role of systemic inflammation on adolescent breast composition and pubertal development among girls. Methods We investigated associations between circulating levels of inflammatory markers (e.g., interleukin-6 (IL-6), tumor necrosis factor receptor 2 (TNFR2), and C-reactive protein (CRP)) at Tanner stages 2 and 4 and breast composition at Tanner stage 4 in a cohort of 397 adolescent girls in Santiago, Chile (Growth and Obesity Cohort Study, 2006–2018). Multivariable linear models were used to examine the association between breast composition and each inflammatory marker, stratifying by Tanner stage at inflammatory marker measurement. Accelerated failure time models were used to evaluate the association between inflammatory markers concentrations at each Tanner stage and time to menarche. Results In age-adjusted linear regression models, a doubling of TNFR2 at Tanner 2 was associated with a 26% (95% CI 7–48%) increase in total breast volume at Tanner 4 and a 22% (95% CI 10–32%) decrease of fibroglandular volume at Tanner 4. In multivariable models further adjusted for body fatness and other covariates, these associations were attenuated to the null. The time to menarche was 3% (95% CI 1–5%) shorter among those in the highest quartile of IL-6 at Tanner 2 relative to those in the lowest quartile in fully adjusted models. Compared to those in the lowest quartile of CRP at Tanner 4, those in the highest quartile experienced 2% (95% CI 0–3%) longer time to menarche in multivariable models. Conclusions Systemic inflammation during puberty was not associated with breast volume or breast density at the conclusion of breast development among pubertal girls after adjusting for body fatness; however, these circulating inflammation biomarkers, specifically CRP and IL-6, may affect the timing of menarche onset.Abstract Background Systemic inflammation may play a role in shaping breast composition, one of the strongest risk factors for breast cancer. Pubertal development presents a critical window of breast tissue susceptibility to exogenous and endogenous factors, including pro-inflammatory markers. However, little is known about the role of systemic inflammation on adolescent breast composition and pubertal development among girls. Methods We investigated associations between circulating levels of inflammatory markers (e.g., interleukin-6 (IL-6), tumor necrosis factor receptor 2 (TNFR2), and C-reactive protein (CRP)) at Tanner stages 2 and 4 and breast composition at Tanner stage 4 in a cohort of 397 adolescent girls in Santiago, Chile (Growth and Obesity Cohort Study, 2006–2018). Multivariable linear models were used to examine the association between breast composition and each inflammatory marker, stratifying by Tanner stage at inflammatory marker measurement. Accelerated failure time models were used to evaluate the association between inflammatory markers concentrations at each Tanner stage and time to menarche. Results In age-adjusted linear regression models, a doubling of TNFR2 at Tanner 2 was associated with a 26% (95% CI 7–48%) increase in total breast volume at Tanner 4 and a 22% (95% CI 10–32%) decrease of fibroglandular volume at Tanner 4. In multivariable models further adjusted for body fatness and other covariates, these associations were attenuated to the null. The time to menarche was 3% (95% CI 1–5%) shorter among those in the highest quartile of IL-6 at Tanner 2 relative to those in the lowest quartile in fully adjusted models. Compared to those in the lowest quartile of CRP at Tanner 4, those in the highest quartile experienced 2% (95% CI 0–3%) longer time to menarche in multivariable models. Conclusions Systemic inflammation during puberty was not associated with breast volume or breast density at the conclusion of breast development among pubertal girls after adjusting for body fatness; however, these circulating inflammation biomarkers, specifically CRP and IL-6, may affect the timing of menarche onset.
dc.identifier.citationBreast Cancer Research. 2020 Oct 01;22(1):104
dc.identifier.doi10.1186/s13058-020-01338-y
dc.identifier.urihttps://doi.org/10.1186/s13058-020-01338-y
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/46947
dc.issue.numeroNo. 104
dc.language.isoen
dc.pagina.final14
dc.pagina.inicio1
dc.revistaBreast Cancer Researches_ES
dc.rights.holderThe Author(s)
dc.subjectSystemic inflammationes_ES
dc.subjectBreast canceres_ES
dc.subjectBreast densityes_ES
dc.subjectMenarchees_ES
dc.subjectAdiposityes_ES
dc.subjectPubertyes_ES
dc.subjectInterleukin-6es_ES
dc.subjectTumor necrosis factor receptor 2es_ES
dc.subjectC-reactive proteines_ES
dc.subject.ddc616.99449
dc.subject.deweyMedicina y saludes_ES
dc.titleAssociation between indicators of systemic inflammation biomarkers during puberty with breast density and onset of menarchees_ES
dc.typeartículo
dc.volumenVol. 22
sipa.codpersvinculados1005923
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