Study Designs in Genomic Epidemiology

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dc.catalogadorvzp
dc.contributor.authorSantos Martin, José Luis
dc.contributor.authorRivadeneira, Fernando
dc.date.accessioned2024-01-19T17:44:46Z
dc.date.available2024-01-19T17:44:46Z
dc.date.issued2020
dc.description.abstractThe choice of an appropriate study design is a critical first step in any genomic epidemiology research, especially considering the current unprecedented capacity of generating massive information derived from genomics and other "-omics” disciplines. In this chapter, we will review the main types of study designs used to discover novel genes or gene variants related to human diseases, as well as to assess their quantitative impact on disease risk. Several study designs are commonly used in the field of epidemiology (for example, cohort, classical case-control, and case-cohort studies). In contrast, other study designs based on the observation of resemblance among relatives come primarily from the field of human genetics, such as family aggregation, adoption, and monozygotic-dizygotic twin studies. Finally, the massive incorporation of genetic markers and next-generation sequencing data has been used in linkage studies of nuclear or multigenerational families, genomic studies of population isolates, and genome-wide association studies.
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/B978-0-12-804572-5.00013-6
dc.identifier.eisbn9780128045879
dc.identifier.isbn9780128045725
dc.identifier.urihttps://doi.org/10.1016/B978-0-12-804572-5.00013-6
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80779
dc.identifier.wosidWOS:000531641800015
dc.information.autorucEscuela de Medicina; Santos Martin Jose Luis; 0000-0003-2895-0369; 1005923
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final106
dc.pagina.inicio99
dc.publisherACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD
dc.revistaPRINCIPLES OF NUTRIGENETICS AND NUTRIGENOMICS: FUNDAMENTALS OF INDIVIDUALIZED NUTRITION
dc.rightsacceso restringido
dc.subjectCase-control
dc.subjectCohort
dc.subjectGenomics
dc.subjectGwas
dc.subjectLinkage
dc.subjectLinkage disequilibrium
dc.subject.ddc610
dc.subject.deweyMedicina y salud
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleStudy Designs in Genomic Epidemiology
dc.typecapítulo de libro
sipa.codpersvinculados1005923
sipa.trazabilidadWOS;05-06-2021
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