Gallbladder disease is associated with insulin resistance in a high risk Hispanic population

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dc.contributor.authorNervi, Flavio
dc.contributor.authorMiquel, Juan Francisco
dc.contributor.authorAlvarez, Manuel
dc.contributor.authorFerreccio, Catterina
dc.contributor.authorGarcia Zattera, Maria Jose
dc.contributor.authorGonzalez, Robinson
dc.contributor.authorPerez Ayuso, Rosa Maria
dc.contributor.authorRigotti, Attilio
dc.contributor.authorVillarroel, Luis
dc.date.accessioned2024-01-10T13:48:42Z
dc.date.available2024-01-10T13:48:42Z
dc.date.issued2006
dc.description.abstractBackground/Aims: We tested whether cholesterol gallstone disease (GS) is associated to insulin resistance and serum C-reactive protein (CRP) in a high risk population.
dc.description.abstractMethods:This was a nested case-control study on 881 Chilean subjects that included clinical examination, abdominal ultrasound and blood chemistries. Insulin resistance was determined by the homeostasis model assessment index (IR-(HOMA)).
dc.description.abstractResults: Compared to controls (n = 582), age and sex adjusted median IR-HOMA was significantly elevated in subjects with GS (n = 299) (P < 0.001). Risks of GS in subjects with insulin resistance and different body mass index (BMI) were: BMI < 25, 2.2 (1.1-4.7); BMI 25-30, 1.5 (0.9-2.5) and BMI > 30, 1.7 (1.0-2.9). Risk of GS in subjects with metabolic syndrome was 1.7 (CI, 1.2-2.5) and with fatty liver, 1.5 (1.1-2.2). Risk of GS in subjects with CRP > 1 mg/dL was 1.0 (0.7-1.7).
dc.description.abstractConclusions: GS is associated to insulin resistance, fatty liver and to metabolic syndrome, but not to serum CRP in a high risk Hispanic population. Insulin resistance could have a major role in the pathogenesis of GS favoring the production of cholesterol supersaturated bile and altering gallbladder function. (c) 2006 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
dc.fechaingreso.objetodigital27-03-2024
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jhep.2006.01.026
dc.identifier.eissn1600-0641
dc.identifier.issn0168-8278
dc.identifier.pubmedidMEDLINE:16516330
dc.identifier.urihttps://doi.org/10.1016/j.jhep.2006.01.026
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79390
dc.identifier.wosidWOS:000239545700019
dc.information.autorucMedicina;Ferreccio F;S/I;99684
dc.information.autorucMatemática;García-Zattera MJ;S/I;14903
dc.information.autorucMedicina;Miquel J;S/I;72216
dc.information.autorucMedicina;Nervi F;S/I;99156
dc.information.autorucMedicina;Pérez-Ayuso R;S/I;100479
dc.information.autorucMedicina;Rigotti A;S/I;68489
dc.information.autorucMedicina;Álvarez M;S/I;6131
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final305
dc.pagina.inicio299
dc.publisherELSEVIER SCIENCE BV
dc.revistaJOURNAL OF HEPATOLOGY
dc.rightsacceso restringido
dc.subjectcholesterol gallstones
dc.subjectinsulin resistance
dc.subjectobesity
dc.subjectmetabolic syndrome
dc.subjectC-reactive protein
dc.subjectHispanics
dc.subjectCORONARY HEART-DISEASE
dc.subjectBILE-ACID SYNTHESIS
dc.subjectGLUCOSE-TOLERANCE
dc.subjectGALLSTONE-DISEASE
dc.subjectCHOLESTEROL CHOLELITHIASIS
dc.subjectCHILEAN HISPANICS
dc.subjectFATTY LIVER
dc.subjectINFLAMMATION
dc.subjectPREVALENCE
dc.subjectATHEROSCLEROSIS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleGallbladder disease is associated with insulin resistance in a high risk Hispanic population
dc.typeartículo
dc.volumen45
sipa.codpersvinculados99684
sipa.codpersvinculados14903
sipa.codpersvinculados72216
sipa.codpersvinculados99156
sipa.codpersvinculados100479
sipa.codpersvinculados68489
sipa.codpersvinculados6131
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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