Predictive accuracy of the pneumonia severity index vs CRB-65 for time to clinical stability: Results from the Community-Acquired Pneumonia Organization (CAPO) International Cohort Study

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dc.contributor.authorArnold, Forest W.
dc.contributor.authorBrock, Guy N.
dc.contributor.authorPeyrani, Paula
dc.contributor.authorRodriguez, Eduardo L.
dc.contributor.authorDiaz, Alejandro A.
dc.contributor.authorRossi, Paolo
dc.contributor.authorRamirez, Julio A.
dc.contributor.authorCAPO
dc.date.accessioned2024-01-10T13:52:22Z
dc.date.available2024-01-10T13:52:22Z
dc.date.issued2010
dc.description.abstractBackground: The Pneumonia Severity Index (PSI) and CRB-65 are scores used to predict mortality in patients with community-acquired pneumonia (CAP). It is unknown how well either score predicts time to clinical stability in hospitalized patients with CAP. Thus, it is also not known which score predicts time to clinical stability better.
dc.description.abstractMethods: A secondary analysis of 3087 patients from the Community-Acquired Pneumonia Organization (CAPO) database was performed. Time-dependent receiver-operator characteristic (ROC) curves for time to clinical stability were calculated for the PSI and CRB-65 scores at day seven of hospitalization. Secondary outcomes were to assess the relationship of the PSI and CRB-65 to in-hospital mortality and length of stay (LOS). ROC curves for LOS and mortality were calculated.
dc.description.abstractResults: The area under the ROC curve (AUC) for time to clinical stability by day seven was 0.638 (95% Cl 0.613, 0.660) when using the PSI, and 0.647 (95% CI 0.619, 0.670) while using the CRB-65. The difference in AUC values was not statistically significant (95% CI for difference of -0.03 to 0.01). However, the difference in the AUC values for discharge within 14 days (0.651 for PSI vs 0.63 for CRB-65, 95% CI for difference 0.001-0.049), and 28-day in-hospital mortality (0.738 for PSI vs 0.69 for CRB-65, 95% CI for difference 0.02-0.082) were both statistically significant.
dc.description.abstractConclusions: This study demonstrates a moderate ability of both the PSI and CRB-65 scores to predict time to clinical stability, and found that the predictive accuracy of the PSI was equivalent to that of the CRB-65 for this outcome. (C) 2010 Elsevier Ltd. All rights reserved.
dc.description.funderNational Institutes of Health
dc.description.funderPfizer
dc.description.funderCubist
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT
dc.description.funderNATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH
dc.description.funderNATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
dc.fechaingreso.objetodigital17-04-2024
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.rmed.2010.05.022
dc.identifier.issn0954-6111
dc.identifier.pubmedidMEDLINE:20576417
dc.identifier.urihttps://doi.org/10.1016/j.rmed.2010.05.022
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79659
dc.identifier.wosidWOS:000283900400019
dc.information.autorucMedicina;Diaz A;S/I;104496
dc.issue.numero11
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final1743
dc.pagina.inicio1736
dc.publisherW B SAUNDERS CO LTD
dc.revistaRESPIRATORY MEDICINE
dc.rightsacceso restringido
dc.subjectCommunity-acquired pneumonia
dc.subjectSeverity of illness index
dc.subjectTime to clinical stability
dc.subjectLOW-RISK PATIENTS
dc.subjectCOMPETING RISK
dc.subjectVALIDATION
dc.subjectMANAGEMENT
dc.subjectRULE
dc.subjectTHERAPY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePredictive accuracy of the pneumonia severity index vs CRB-65 for time to clinical stability: Results from the Community-Acquired Pneumonia Organization (CAPO) International Cohort Study
dc.typeartículo
dc.volumen104
sipa.codpersvinculados104496
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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