Is L-methionine a trigger factor for Alzheimer’s-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice

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dc.contributor.authorTapia Rojas, Cheril Cecilia
dc.contributor.authorLindsay, Carolina B.
dc.contributor.authorMontecinos Oliva, Carla
dc.contributor.authorArrazola Tello, Macarena Soledad.
dc.contributor.authorRetamales, Rocio M.
dc.contributor.authorInestrosa Cantín, Nibaldo
dc.contributor.authorBunout, Daniel
dc.contributor.authorHirsch, Sandra.
dc.date.accessioned2019-10-17T14:26:58Z
dc.date.available2019-10-17T14:26:58Z
dc.date.issued2015
dc.date.updated2019-10-14T18:54:12Z
dc.description.abstractAbstract Background L-methionine, the principal sulfur-containing amino acid in proteins, plays critical roles in cell physiology as an antioxidant and in the breakdown of fats and heavy metals. Previous studies suggesting the use of L-methionine as a treatment for depression and other diseases indicate that it might also improve memory and propose a role in brain function. However, some evidence indicates that an excess of methionine can be harmful and can increase the risk of developing Type-2 diabetes, heart diseases, certain types of cancer, brain alterations such as schizophrenia, and memory impairment. Results Here, we report the effects of an L-methionine-enriched diet in wild-type mice and emphasize changes in brain structure and function. The animals in our studypresented 1) higher levels of phosphorylated tau protein, 2) increased levels of amyloid-β (Aβ)-peptides, including the formation of Aβ oligomers, 3) increased levels of inflammatory response,4) increased oxidative stress, 5) decreased level of synaptic proteins, and 6) memory impairment and loss. We also observed dysfunction of the Wnt signaling pathway. Conclusion Taken together, the results of our study indicate that an L-methionine-enriched diet causes neurotoxic effects in vivo and might contribute to the appearance of Alzheimer’s-like neurodegeneration.
dc.fuente.origenBiomed Central
dc.identifier.citationMolecular Neurodegeneration. 2015 Nov 21;10(1):62
dc.identifier.doi10.1186/s13024-015-0057-0
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/26697
dc.issue.numeroNo. 62
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final17
dc.pagina.inicio1
dc.revistaMolecular Neurodegenerationes_ES
dc.rightsacceso abierto
dc.rights.holderTapia-Rojas et al.
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherEnfermedades neurodegenerativas - Investigacioneses_ES
dc.subject.otherEnfermedad de Alzheimer - Terapiaes_ES
dc.subject.otherMetioninaes_ES
dc.titleIs L-methionine a trigger factor for Alzheimer’s-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type micees_ES
dc.typeartículo
dc.volumenVol. 10
sipa.codpersvinculados99331
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